143062-73-1 Usage
General Description
(1R,2S)-Fluorocyclopropylamine tosylate is a chemical compound that consists of a fluorine-substituted cyclopropylamine with added tosylate group. The (1R,2S) designation indicates the stereochemistry of the molecule, where the fluorine and tosylate groups are attached to specific positions in the cyclopropane ring. (1R,2S)-Fluorocyclopropylamine tosylate is commonly used as a precursor in organic synthesis, particularly in the preparation of fluorinated pharmaceuticals and agrochemicals. The presence of the fluorine atom in the cyclopropane ring imparts unique properties to the molecule, making it useful in the development of novel chemical compounds. Additionally, the tosylate group serves as a leaving group in various chemical reactions, allowing for the manipulation of the molecule's structure. Overall, (1R,2S)-Fluorocyclopropylamine tosylate is a valuable building block in the development of diverse chemical compounds with potential applications in medicine, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 143062-73-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,0,6 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143062-73:
(8*1)+(7*4)+(6*3)+(5*0)+(4*6)+(3*2)+(2*7)+(1*3)=101
101 % 10 = 1
So 143062-73-1 is a valid CAS Registry Number.
143062-73-1Relevant articles and documents
Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions
Matsuo, Jun-Ichi,Tani, Yu-Ichirou,Hayakawa, Yu-Ichirou
, p. 464 - 465 (2004)
cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoin-dol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.
Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859
Tamura,Hashimoto,Kobayashi,Katoh,Nakatani,Kamada,Hayakawa,Akiba,Terashima
, p. 3483 - 3486 (2007/10/02)
The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro