143161-04-0

Basic information

• Product Name: 2H-1,4-Benzothiazine-2-acetic acid, 3,4-dihydro-3-oxo-4-(phenylmethyl)-, ethyl ester
• CAS NO: 143161-04-0
• Molecular Formula: C19H19NO3S
• Molecular Weight: 341.431
• Mol File: 143161-04-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-1,4-Benzothiazine-2-acetic acid, 3,4-dihydro-3-oxo-4-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,4-Benzothiazine-2-acetic acid, 3,4-dihydro-3-oxo-4-(phenylmethyl)-, ethyl ester(143161-04-0)
• EPA Substance Registry System: 2H-1,4-Benzothiazine-2-acetic acid, 3,4-dihydro-3-oxo-4-(phenylmethyl)-, ethyl ester(143161-04-0)

Safety Data

• Hazardous Substances Data: 143161-04-0(Hazardous Substances Data)

Upstream product

• 82191-17-1 ethyl 2-(3,4-dihydro-3-oxo-2H-1,4-benzothiazin-2-yl)acetate 

Downstream Products

• 143162-99-6 2-[4-Benzyl-3, 4-dihydro-3-oxo-2H-1, 4-benzothiazin-2-yl]acetic acid 

Relevant articles and documents

Identification of novel potent bicyclic peptide deformylase inhibitors

Screening of our compound collection using Staphylococcus aureus Ni-Peptide deformylase (PDF) afforded a very potent PDF inhibitor with an IC50 in the low nanomolar range but with poor antibacterial activity (MIC). Three-dimensional structural information obtained from Pseudomonas aeruginosa Ni-PDF complexed with the inhibitor suggested the synthesis of a variety of analogues that would maintain high binding affinity while attempting to improve antibacterial activity. Many of the compounds synthesized proved to be excellent PDF-Ni inhibitors and some showed increased antibacterial activity in selected strains.