1431660-75-1

Basic information

• Product Name: 5-ethyl-3-phenyl-1H-indole
• Synonyms: 5-ethyl-3-phenyl-1H-indole
• CAS NO: 1431660-75-1
• Molecular Weight: 221.302
• Mol File: 1431660-75-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-ethyl-3-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ethyl-3-phenyl-1H-indole(1431660-75-1)
• EPA Substance Registry System: 5-ethyl-3-phenyl-1H-indole(1431660-75-1)

Safety Data

• Hazardous Substances Data: 1431660-75-1(Hazardous Substances Data)

Upstream product

• 5470-36-0 [2-(phenyl)ethyl]hydrazine hydrochloride 
• 110391-94-1 4-ethyl-4-methoxycyclohexa- 2,5-dien-1-one 
• 103-63-9 1-phenyl-2-bromoethane 
• 22955-65-3 1-ethyl-4-nitrosobenzene 
• 1019610-08-2 N-(2-phenylethyl)pyridin-3-amine 
• 1739-00-0 (N-phenyl)phenylethylamine 
• 64-04-0 phenethylamine 

Relevant articles and documents

Acid mediated coupling of aliphatic amines and nitrosoarenes to indoles

Traditionally, amines react with nitrosoarenes to provide the corresponding imines or azo compounds. Herein, we report an acid mediated annulation reaction of aliphatic amines and nitrosoarenes to provide indole derivatives. The elusive direct annulation of aliphatic amines and nitrosoarenes via simultaneous C-C and C-N bond formation was achieved under metal free conditions. This conceptually novel method for indole synthesis does not require pre-functionalization steps for the new C-C and C-N bond formation. The method has been applied for an elegant synthesis of nor-neocryptolepine and neocryptolepine.