1431697-94-7 Usage
Description
Lorcaserin hydrochloride is a hydrochloride derivative of lorcaserin, a compound that acts as a serotonergic agonist and appetite suppressant. It is obtained by reacting lorcaserin with one equivalent of hydrochloric acid and is characterized by its role in the treatment of obesity. Lorcaserin hydrochloride contains a lorcaserin(1+) cation and is classified as an anorectic, which means it has the property of reducing appetite. Additionally, it is regulated as a Schedule IV compound in the United States.
Uses
1. Used in Pharmaceutical Industry:
Lorcaserin hydrochloride is used as an anti-obesity drug for the treatment of obesity. It functions as a selective serotonin 5-HT2C receptor agonist, which helps in suppressing appetite and promoting weight loss.
2. Used in Research and Development:
Lorcaserin hydrochloride is utilized as an analytical reference material to prepare and study the structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin). This helps in understanding the compound's interaction with the serotonin 5-HT2C receptor and its potential applications in the treatment of obesity.
3. Used in Addiction Treatment:
Lorcaserin hydrochloride has been found to decrease oxycodone intake and has positive effects on self-administration and relapse vulnerability in rats. This suggests that it may have potential applications in the treatment of addiction, particularly to opioids.
Check Digit Verification of cas no
The CAS Registry Mumber 1431697-94-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,1,6,9 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1431697-94:
(9*1)+(8*4)+(7*3)+(6*1)+(5*6)+(4*9)+(3*7)+(2*9)+(1*4)=177
177 % 10 = 7
So 1431697-94-7 is a valid CAS Registry Number.
1431697-94-7Relevant articles and documents
Synthesis process of weight-reducing drug lorcaserin hydrochloride intermediate
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, (2020/04/17)
The invention discloses a synthesis process of a weight-reducing drug lorcaserin hydrochloride intermediate (compound V), which is characterized in that p-chlorophenylethylamine is used as a raw material, acetic anhydride is subjected to acylation to prot
A Concise Synthesis of Racemic Lorcaserin
Xu, Bin,Su, Jincai,Wang, Jing,Zhou, Guo-Chun
, p. 770 - 774 (2016/08/09)
We report herein the concise synthesis of racemic lorcaserin (±)-1, which is an anti-obesity drug. The synthetic route involved the key synthesis of an asymmetrical imide intermediate 11 and its efficient reduction. Imide 11 was synthesized directly by the reaction of nitrile 9 with acid 10. The reducing system of NaBH4, AlCl3, and trimethylsilyl chloride efficiently fulfilled the reduction of imide 11 to amine 8a, which could be converted to (±)-1 via Friedel-Crafts reaction as reported. This route afforded 69% two-step yield of 8a from 9 via 11, and the concise synthesis of (±)-1 was completed in three steps. This route offers an alternative pathway to the synthesis of (±)-1 and its analogues.
PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES
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Page/Page column 66, (2015/01/07)
The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.
