14320-58-2

Basic information

• Product Name: 4-methyl-2-phenylpentanoic acid
• CAS NO: 14320-58-2
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.2542
• Mol File: 14320-58-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 298.3°C at 760 mmHg
• Flash Point: 195.4°C
• Density: 1.044g/cm³
• Vapor Pressure: 0.000573mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 4-methyl-2-phenylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-phenylpentanoic acid(14320-58-2)
• EPA Substance Registry System: 4-methyl-2-phenylpentanoic acid(14320-58-2)

Safety Data

• Hazardous Substances Data: 14320-58-2(Hazardous Substances Data)

Usage

Description

4-methyl-2-phenylpentanoic acid, also known as 4-methyl-2-phenylvaleric acid, is an organic compound characterized by its chemical formula C12H16O2. It is a carboxylic acid that exists as a white crystalline solid at room temperature. 4-methyl-2-phenylpentanoic acid is recognized for its sweet, floral odor and is valued for its potential therapeutic properties, such as anti-inflammatory and antioxidant effects.

Uses

Used in Pharmaceutical Industry:
4-methyl-2-phenylpentanoic acid is used as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and properties, contributing to the development of new medications.
Used in Fragrance Industry:
4-methyl-2-phenylpentanoic acid is used as a fragrance ingredient for its sweet, floral scent, enhancing the olfactory profiles of various products in the fragrance sector.
Used in Organic Synthesis:
4-methyl-2-phenylpentanoic acid serves as a building block in the synthesis of other organic compounds, playing a crucial role in the creation of diverse chemical entities for various applications.
Used in Therapeutic Applications:
4-methyl-2-phenylpentanoic acid is studied for its potential as an anti-inflammatory and antioxidant agent, indicating its use in the development of treatments for conditions that could benefit from these properties.

Upstream product

• 492-38-6 2-phenylacrylic acid 
• 1068-55-9 isopropylmagnesium chloride 
• 5558-31-6 4-methyl-2-phenylpentanenitrile 
• 103-82-2 phenylacetic acid 
• 78-77-3 Isobutyl bromide 
• 140-29-4 phenylacetonitrile 
• 513-38-2 Isobutyl iodide 
• 20215-56-9 5,5-dimethyl-3-phenyldihydrofuran-2(3H)-one 
• 101-41-7 benzeneacetic acid methyl ester 
• 58929-89-8 methyl 4-methyl-2-phenylpentanoate 
• 2049-94-7 (3-methylbutyl)benzene 
• 124-38-9 carbon dioxide 
• 100-42-5 styrene 
• 75-26-3 isopropyl bromide 

Downstream Products

• 7473-03-2 N-ethyl-2-isobutyl-2-phenyl-malonamic acid 
• 51631-97-1 4-methyl-2-phenylpentanoyl chloride 
• 124888-45-5 4-methyl-2-phenyl-pentanoic acid isopropyl ester 
• 851166-03-5 ((Z)-1-Isopropoxy-4-methyl-2-phenyl-pent-1-enyloxy)-trimethyl-silane 
• 407578-54-5 isobutylphenylketene 
• 145074-64-2 1-diazo-5-methyl-3-phenyl-2-hexanone 
• 605680-32-8 N-methoxy-N-methyl-4-methyl-2-phenylpentanamide 
• 1392493-50-3 4-methyl-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)pentanamide 
• 605680-33-9 5-methyl-3-phenyl-2-hexanol 
• 610791-34-9 2-amino-5-methyl-3-phenylhexane 
• 605680-34-0 2-azido-5-methyl-3-phenylhexane 
• 103392-12-7 5-Methyl-3-phenyl-2-hexanone 

Relevant articles and documents

Iron-Catalyzed Asymmetric Decarboxylative Azidation

The first iron-catalyzed asymmetric azidation of benzylic peresters has been reported with trimethylsilyl azide (TMSN3) as the azido source. Hydrocarbon radicals that lack of strong interactions were capable to be enantioselectively azidated. The reaction features good functional group tolerance, high yields, and mild conditions. The chiral benzylic azides can further be used in click reaction, phosphoramidation, and reductive amination, which demonstrate the synthetic values of this reaction.

Photocarboxylation of Benzylic C-H Bonds

The carboxylation of sp3-hybridized C-H bonds with CO2 is a challenging transformation. Herein, we report a visible-light-mediated carboxylation of benzylic C-H bonds with CO2 into 2-arylpropionic acids under metal-free conditions. Photo-oxidized triisopropylsilanethiol was used as the hydrogen atom transfer catalyst to afford a benzylic radical that accepts an electron from the reduced form of 2,3,4,6-tetra(9H-carbazol-9-yl)-5-(1-phenylethyl)benzonitrile generated in situ. The resulting benzylic carbanion reacts with CO2 to generate the corresponding carboxylic acid after protonation. The reaction proceeded without the addition of any sacrificial electron donor, electron acceptor or stoichiometric additives. Moderate to good yields of the desired products were obtained in a broad substrate scope. Several drugs were successfully synthesized using the novel strategy.

Preparation of aryl alkyl ketenes

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