1432024-31-1

Basic information

• Product Name: C₂₂H₁₈N₂O₆S
• Synonyms: C₂₂H₁₈N₂O₆S
• CAS NO: 1432024-31-1
• Molecular Weight: 438.461
• Mol File: 1432024-31-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₈N₂O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₈N₂O₆S(1432024-31-1)
• EPA Substance Registry System: C₂₂H₁₈N₂O₆S(1432024-31-1)

Safety Data

• Hazardous Substances Data: 1432024-31-1(Hazardous Substances Data)

Upstream product

• 127-71-9 sulfabenzamide 
• 1379522-28-7 ethyl 4-(2-(dimethylamino)vinyl)-5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylate 
• 13156-09-7 4,5,5-trimethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester 
• 105-53-3 diethyl malonate 

Relevant articles and documents

C1 and N5 derivatives of cerpegin: Synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome

Thirty-two new derivatives of cerpegin (1,1,5-trimethylfuro[3,4-c]pyridine- 3,4-dione) were designed and synthesized in high yield by a new method, combining several C1 and N5 substituents. All compounds were tested for their inhibitory effect on the CT-L, T-L and PA proteolytic activities of a purified mammalian 20S proteasome. Only one molecule inhibited both CT-L and PA activities. Sixteen molecules specifically inhibited PA at the micromolar range, out of which fourteen had IC50 values around 5 μM and two had IC50 values closer to 2 μM. Except in one case, neither calpain I nor cathepsin B was inhibited. In silico docking suggests a unique mode of binding of the most efficient compounds to the β1 catalytic site (PA activity) in relation to the chemical nature of C1 substituents.