14321-25-6Relevant articles and documents
A NEW SYNTHESIS OF α-CYANOAMINES. LEWIS ACID PROMOTED NUCLEOPHILIC SUBSTITUTION OF α-SILOXYAMINES USING TRIMETHYLSILYL CYANIDE
Tokitoh, Norihiro,Okazaki, Renji
, p. 241 - 242 (1985)
α-Siloxyamines obtained from tertiary amines via their N-oxides were treated with titanium tetrachloride and trimethylsilyl cyanide to give α-cyanated tertiary amines in good yields.
RuO4-mediated oxidation of tertiary amines. stereoelectronic effects
Petride, Horia,Florea, Cristina,H?rtopeanu, Anca,Stavarache, Cristina
, p. 89 - 96 (2021/02/05)
Tertiary amines like PhCH2-NMe-CH2R (R = H, Me, CN) underwent RuO4-mediated oxidation by attack at all three N-α-positions. The various reaction products were classified in three groups, according to the functionalized sit
Nano cobalt-copper ferrite catalyzed regioselective α-C(sp3)–H cyanation of amines: Secondary, tertiary, and drug molecules
Heidarian, Mahdi,Moghaddam, Firouz Matloubi,Pourkaveh, Raheleh
, (2020/11/03)
Oxidative cyanation of sp3C–H bonds at the α position of amines was achieved using CoCuFe2O4 as a catalyst and NaCN as an inexpensive cyanide source at room temperature. CoCuFe2O4 was found to be an active catalyst for Csp [3]-Csp coupling, efficiently delivering valuable α-aminonitriles from tertiary/secondary amines in good yields. The corresponding products were obtained with high selectivity toward α position. In addition, functional group tolerance offered the opportunity for application in late-stage functionalization of biologically active molecules. This transformation proceeds convenient on a gram-scale, and the catalyst can be reused for several runs with consistent catalytic activity.