143216-81-3 Usage
Description
(3beta,4alpha,17Z)-17-(methoxyimino)gona-1,5(10),6,8,11,13-hexaene-3,4-diol is a complex organic compound belonging to the class of gonanes and derivatives. It is a steroid derivative with a hexaene-3,4-diol moiety, a methoxyimino group, and various other functional groups. (3beta,4alpha,17Z)-17-(methoxyimino)gona-1,5(10),6,8,11,13-hexaene-3,4-diol may possess potential biological activities and is of interest in the fields of medicine and pharmacology. Further research is required to fully understand its properties and potential applications.
Uses
Used in Pharmaceutical Industry:
(3beta,4alpha,17Z)-17-(methoxyimino)gona-1,5(10),6,8,11,13-hexaene-3,4-diol is used as a pharmaceutical compound for its potential biological activities. Its complex structure and functional groups may contribute to its therapeutic effects, making it a promising candidate for drug development and medicinal applications.
Used in Research and Development:
(3beta,4alpha,17Z)-17-(methoxyimino)gona-1,5(10),6,8,11,13-hexaene-3,4-diol is used as a research compound for studying its properties, potential applications, and biological activities. Further research is needed to fully understand its potential and to explore its use in various fields, such as medicine, pharmacology, and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 143216-81-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,2,1 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 143216-81:
(8*1)+(7*4)+(6*3)+(5*2)+(4*1)+(3*6)+(2*8)+(1*1)=103
103 % 10 = 3
So 143216-81-3 is a valid CAS Registry Number.
143216-81-3Relevant articles and documents
Synthesis of the Putative Active Metabolites of the Cyclopentaphenanthrenes. Synthesis of the trans-3,4-Dihydro 3,4-Diol and syn-3,4-Diol 1,2-Epoxide Derivatives of the Mutagen 15,16-Dihydrocyclopentaphenanthren-17-one
Woski, Stephen A.,Koreeda, Masato
, p. 5736 - 5741 (2007/10/02)
The first synthesis of the trans-dihydro diol and syn-diol epoxide derivatives of a biologically active cyclopentaphenanthrene is described.The cyclopentaphenanthrene skeleton is rapidly and efficiently assembled utilizing the Lewis acid-catalyzed Diels-Alder reaction of 1,2-dihydro-7-methoxy-4-vinylnaphthalene (5) with an α-heterosubstituted cyclopentenone, a "cyclopentynone" equivalent.It was found that the Diels-Alder reaction of α-(phenylselenenyl)- (6a) or α-bromocyclopentenone (6b) with 5 in the presence of 1.5 equiv of SnCl4 followed by elimination with hydrogen peroxide or DBU produced the key intermediate 15,16-dihydro-3-methoxycyclopentaphenanthren-17-one (10) in 28percent or 59percent overall yield, respectively.The synthesis of the A-ring metabolites features the use of a unique methoxime protecting group for the 17-ketone.The deprotection of the 17-methoxime group of the highly acid-sensitive 3,4-trans-dihydro 3,4-diol bis(TBDMS) ether 15b was achieved through the use of the low-valent titanium reagent produced upon reduction of TiCl3-3THF by DIBAL-H (51percent).Treatment of bis-(TBDMS) ether 16 with TBAF in THF provided the desired 3,4-trans-dihydro 3,4-diol (3) (83percent), thus achieving the synthesis of 3 in 10 steps in 9.6percent overall yield from 6b.In addition, the bay-region syn-3,4-diol 1,2-epoxide (4a) was also synthesized from 3 in two steps in 59percent overall yield.
