1432446-07-5Relevant articles and documents
Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors
Meng, Zhaoyang,Ciavarri, Jeffrey P.,McRiner, Andrew,Zhao, Yinyan,Zhao, Lianyun,Reddy, Panduranga Adulla,Zhang, Xingmin,Fischmann, Thierry O.,Whitehurst, Charles,Arshad Siddiqui
, p. 2863 - 2867 (2013/06/26)
Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2.