143289-00-3Relevant articles and documents
Determination of the absolute configuration of the active amlodipine enantiomer as (-)-S: A correction
Goldmann,Stoltefuss,Born
, p. 3341 - 3344 (1992)
The active (-) enantiomer of amlodipine was originally reported to have R configuration. This does not concur with other 1,4-dihydropyridines with known absolute configuration. This configuration has now been determined by X-ray structural analysis using (1S)-camphanic acid and (S)-2-methoxy-2- phenylethanol as chiral probes. Both determinations gave the S configuration for the amlodipine (-) enantiomer with the greater Ca-antagonistic activity.