143313-51-3

Basic information

• Product Name: AC-YVAD-CHO
• Synonyms: N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE;N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE);N-ACETYL-TYR-VAL-ALA-GLU-AL;N-AC-TYR-VAL-ALA-ASP-CHO;N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE);TYR-VAL-ALA-ASP-CHO;YVAD-CHO;ICE INHIBITOR
• CAS NO: 143313-51-3
• Molecular Formula: C23H32N4O8
• Molecular Weight: 492.52
• Product Categories: Caspases/Apoptosis;peptide;Pepetides;peptides
• Mol File: 143313-51-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 841.9 °C at 760 mmHg
• Flash Point: 463 °C
• Appearance: /
• Density: 1.276 g/cm³
• Vapor Pressure: 4.2E-30mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: −20°C
• PKA: 4.20±0.10(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: AC-YVAD-CHO(CAS DataBase Reference)
• NIST Chemistry Reference: AC-YVAD-CHO(143313-51-3)
• EPA Substance Registry System: AC-YVAD-CHO(143313-51-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 143313-51-3(Hazardous Substances Data)

Usage

Description

AC-YVAD-CHO is an acetylated form of the caspase-1 inhibitor YVAD-CHO, acting as a potent, specific, and reversible inhibitor of caspases-1, -4, and -5. It selectively inhibits caspase-1 over other caspases, making it a valuable tool in studying the roles of these enzymes in various biological processes.

Uses

Used in Pharmaceutical Research:
AC-YVAD-CHO is used as a research tool for studying the role of caspases-1, -4, and -5 in apoptosis and inflammation. Its specificity and potency make it a valuable compound in understanding the mechanisms of cell death and immune response.
Used in Inflammation and Autoimmune Disease Research:
AC-YVAD-CHO is used as an inhibitor to investigate the involvement of caspases-1, -4, and -5 in the activation of interleukin-1β (IL-1β) and other inflammatory processes. This helps in understanding the pathogenesis of various inflammatory and autoimmune diseases.
Used in Acute Pancreatitis Treatment:
AC-YVAD-CHO is used as a therapeutic agent in a mouse model of cerulein-induced acute pancreatitis. It reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as pyroptosis of pancreatic cells, suggesting its potential use in treating acute pancreatitis.
Used in Infection Susceptibility Studies:
AC-YVAD-CHO is used to study the relationship between caspase inhibition and susceptibility to lethal E. coli infection. It increases susceptibility to infection but prevents LPS-induced death in mice, providing insights into the complex interplay between the immune system and caspase activity.
Used in Cell Death Pathway Research:
AC-YVAD-CHO is used as a specific inhibitor of caspases-1, -4, and -5 to investigate their roles in cell death pathways. This helps researchers understand the molecular mechanisms underlying various diseases and conditions associated with cell death.

InChI:InChI=1/C23H32N4O8/c1-12(2)20(23(35)27-21(33)13(3)24-16(11-28)10-19(31)32)26-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,24,30H,9-10H2,1-4H3,(H,25,29)(H,26,34)(H,31,32)(H,27,33,35)/t13-,16-,18-,20-/m0/s1