143327-79-1Relevant articles and documents
Synthesis of 3′-triazoyl-dinucleotides as precursors of stable Phe-tRNAPhe and Leu-tRNALeu analogues
Santarem, Marco,Fonvielle, Matthieu,Sakkas, Nicolas,Laisné, Guillaume,Chemama, Maryline,Herbeuval, Jean-Philippe,Braud, Emmanuelle,Arthur, Michel,Etheve-Quelquejeu, Mélanie
, p. 3231 - 3233 (2014)
We report here the synthesis of stable Phe-tRNAPhe and Leu-tRNALeu analogues containing a 1,2,3-triazole ring instead of the ribose-amino acid ester bond. The 1,2,3-triazole ring is generated by dipolar cycloaddition of alkyne Phe and Leu analogues to 3′-azido-3′- deoxyadenosine via the CuI-catalysed Huisgen, Meldal, Sharpless 1,3-cycloaddition. The corresponding triazoyl pdCpA dinucleotides, obtained by classical phosphoramidite chemistry, were enzymatically ligated to 22-nt or 74-nt RNA generating stable Phe-tRNAPhe analogues containing the acceptor stem or full tRNA moieties, respectively. These molecules represent useful tools to study the contribution of the RNA and amino acid moieties in stabilization of aminoacyl-tRNA/protein complexes.
Triazolo-peptidomimetics: novel radiolabeled minigastrin analogs for improved tumor targeting
Grob, Nathalie M.,H?ussinger, Daniel,Deupi, Xavier,Schibli, Roger,Behe, Martin,Mindt, Thomas L.
supporting information, p. 4484 - 4495 (2020/06/08)
MG11 is a truncated analog of minigastrin, a peptide with high affinity and specificity toward the cholecystokinin-2 receptor (CCK2R), which is overexpressed by different tumors. Thus, radiolabeled MG11 derivatives have great potential for use in cancer d
As cell necrosis inhibitors of the indole compounds (by machine translation)
-
Paragraph 0223; 0224; 0234; 0235; 0236, (2016/10/09)
The invention relates to chemical formula (1) indole compounds, or its pharmaceutically acceptable salt or isomer, and in containing the same as the characteristic, as an active ingredient for the prevention or treatment of cell necrosis and its associated disease composition and method of manufacturing. (by machine translation)
Synthesis of 3′-triazoyl-dinucleotides as precursors of stable Phe-tRNAPhe and Leu-tRNALeu analogues
Santarem, Marco,Fonvielle, Matthieu,Sakkas, Nicolas,Laisné, Guillaume,Chemama, Maryline,Herbeuval, Jean-Philippe,Braud, Emmanuelle,Arthur, Michel,Etheve-Quelquejeu, Mélanie
, p. 3231 - 3233 (2015/02/19)
We report here the synthesis of stable Phe-tRNAPhe and Leu-tRNALeu analogues containing a 1,2,3-triazole ring instead of the ribose-amino acid ester bond. The 1,2,3-triazole ring is generated by dipolar cycloaddition of alkyne Phe and Leu analogues to 3′-azido-3′-deoxyadenosine via the CuI-catalysed Huisgen, Meldal, Sharpless 1,3-cycloaddition. The corresponding triazoyl pdCpA dinucleotides, obtained by classical phosphoramidite chemistry, were enzymatically ligated to 22-nt or 74-nt RNA generating stable Phe-tRNAPhe analogues containing the acceptor stem or full tRNA moieties, respectively. These molecules represent useful tools to study the contribution of the RNA and amino acid moieties in stabilization of aminoacyl-tRNA/protein complexes.