1433607-45-4

Basic information

• Product Name: (3R)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5ylidene)amino)oxy)methyl)pyrrolidine
• Synonyms: (3R)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5ylidene)amino)oxy)methyl)pyrrolidine
• CAS NO: 1433607-45-4
• Molecular Weight: 546.645
• Mol File: 1433607-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5ylidene)amino)oxy)methyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5ylidene)amino)oxy)methyl)pyrrolidine(1433607-45-4)
• EPA Substance Registry System: (3R)-N-Boc-3-(((((E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5ylidene)amino)oxy)methyl)pyrrolidine(1433607-45-4)

Safety Data

• Hazardous Substances Data: 1433607-45-4(Hazardous Substances Data)

Upstream product

• 138108-72-2 tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate 
• 1067230-65-2 (R)-tert-butyl 3-(bromomethyl)pyrrolidine-1-carboxylate 
• 1433605-21-0 (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime 

Relevant articles and documents

QUINAZOLINE DERIVATIVES WITH HSP90 INHIBITORY ACTIVITY

Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.