1433750-55-0

Basic information

• Product Name: 4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
• Synonyms: 4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)
• CAS NO: 1433750-55-0
• Molecular Weight: 486.573
• Mol File: 1433750-55-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)(1433750-55-0)
• EPA Substance Registry System: 4,4'-(naphthalen-1-ylmethanediyl)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)(1433750-55-0)

Safety Data

• Hazardous Substances Data: 1433750-55-0(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 100-63-0 phenylhydrazine 
• 66-77-3 1-naphthaldehyde 
• 89-25-8 edaravone 
• 141-97-9 ethyl acetoacetate 
• 65756-54-9 1-(naphthalen-1-yl)-N-phenylmethanimine oxide 

Relevant articles and documents

Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy

Serine, the source of the one-carbon units essential for de novo purine and deoxythymidine synthesis plays a crucial role in the growth of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first, rate-limiting step in de novo serine biosynthesis has become a promising target for the cancer treatment. Here we identified H-G6 as a potential PHGDH inhibitor from the screening of an in-house small molecule library based on the enzymatic assay. We adopted activity-directed combinatorial chemical synthesis strategy to optimize this hit compound. Compound b36 was found to be the noncompetitive and the most promising one with IC50 values of 5.96 ± 0.61 μM against PHGDH. Compound b36 inhibited the proliferation of human breast cancer and ovarian cancer cells, reduced intracellular serine synthesis, damaged DNA synthesis, and induced cell cycle arrest. Collectively, our results suggest that b36 is a novel PHGDH inhibitor, which could be a promising modulator to reprogram the serine synthesis pathway and might be a potential anticancer lead worth further exploration.

Synthetic 4,4′-(Arylmethylene)bis(1H-pyrazol-5-ols): Efficient Radical Scavengers

Functionalized 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) 1-22 were screened for their antioxidant activity. Antioxidant activity was performed by measuring their radical scavenging activity. These compounds demonstrated diverse in vitro DPPH radical scave

Sulfonated nanohydroxyapatite functionalized with 2-aminoethyl dihydrogen phosphate (HAP@AEPH2-SO3H) as a new recyclable and eco-friendly catalyst for rapid one-pot synthesis of 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s

Sulfonated nanohydroxyapatite functionalized with 2-aminoethyl dihydrogen phosphate (HAP@AEPH2-SO3H), a new green, recyclable solid acid catalyst, was prepared and characterized using FT-IR, XRD, SEM, TEM and TGA/DTA techniques. The