143382-04-1

Basic information

• Product Name: (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid
• Synonyms: (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid
• CAS NO: 143382-04-1
• Molecular Weight: 393.44
• Mol File: 143382-04-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid(143382-04-1)
• EPA Substance Registry System: (S)-2-((S)-2-((S)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)propanoic acid(143382-04-1)

Safety Data

• Hazardous Substances Data: 143382-04-1(Hazardous Substances Data)

Upstream product

• 215596-29-5 methyl acetyl-L-tyrosyl-L-valyl-L-alaninate 

Downstream Products

• 147395-39-9 Ac-Tyr-Val-Ala-D-Asp(O^tBu)-H dimethyl acetal 
• 147395-39-9 Ac-Tyr-Val-Ala-Asp(O^tBu)-H dimethyl acetal 
• 147395-39-9 Ac-Tyr-Val-Ala-(RS)-Asp(O^tBu)-H dimethyl acetal 

Relevant articles and documents

(3R)-3-amino-4-carboxybutyraldehyde derivatives inhibiting the release of interleukin-1/beta

The invention relates to a new (3R)-3-amino-4-carboxybutyraldehyde derivatives of general formula(I) wherein X represents a C1-4alkyloxycarbonyl, an optionally substituted phenyl-(C1-2alkyloxy)-carbonyl, a C1-4alkylcarbonyl or an optionally substituted phenyl-(C1-3alkyl)-carbonyl group, n represents 1 or 0, Y represents, in the case when n=1, a tetrapeptide of general formula Y4-Y3-Y2-Y1, a tripeptide of general formula Y3-Y2-Y1or a dipeptide of general formula Y2-Y1or an amino acid residue of general formula Y1, or in the case when n=0, an α-hydroxyacyl-tripeptide of general formula Q4-Y3-Y2-Y1, an α-hydroxyacyl-dipeptide of general formula Q3-Y2-Y1or an α-hydroxyacyl-aminoacyl residue of general formula Q2-Y1; wherein Y1-Y4represent a residue selected from the group of the following L- or D-amino acids: alanine, alloisoleucine, cyclohexyl-glycine, phenyl-alanine, glutamine, histidine, isoleucine, leucine, lysine, methionine, pipecolic acid, proline, tyrosine and valine; and Q2-Q4represent an acyl group selected from the following α-hydroxyacids of R or S configuration: 2-cycloheptyl-2-hydroxy-acetic acid, 2-cyclohexyl-2-hydroxyacetic acid, 3-cyclohexyllactic acid, 3-phenyllactic acid, 2-hydroxy-3-methylbutyric acid, 2-hydroxy-3-methylvaleric acid, mandelic acid or lactic acid, and salts thereof formed with organic or inorganic bases, and pharmaceutical compositions containing the same. The compounds of general formula (I) of the invention are valuable inhibitors of the interleukin-1β converting enzyme.