143415-62-7

Basic information

• Product Name: BOC-L-4-TERT-BUTYL-PHE
• Synonyms: (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONIC ACID;RARECHEM BK PT 0188;N-ALPHA-T-BUTOXYCARBONYL-(4-T-BUTYL)-L-PHENYLALANINE;N-ALPHA-T-BUTOXYCARBONYL-P-T-BUTYL-L-PHENYLALANINE;BOC-P-TBU-L-PHE-OH;BOC-P-TBU-PHENYLALANINE;BOC-P-TBU-PHE-OH;BOC-PHE(4-TBU)-OH
• CAS NO: 143415-62-7
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.41
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids
• Mol File: 143415-62-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 461.413 °C at 760 mmHg
• Flash Point: 232.855 °C
• Appearance: /
• Density: 1.088 g/cm³
• Vapor Pressure: 2.61E-09mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: -15°C
• PKA: 3.93±0.10(Predicted)
• CAS DataBase Reference: BOC-L-4-TERT-BUTYL-PHE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-4-TERT-BUTYL-PHE(143415-62-7)
• EPA Substance Registry System: BOC-L-4-TERT-BUTYL-PHE(143415-62-7)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 143415-62-7(Hazardous Substances Data)

Usage

General Description

BOC-L-4-tert-butyl-Phe, also known as (S)-tert-butyl 4-((tert-butoxycarbonyl)amino)phenylalaninate, is a chemical compound used in the synthesis of peptides and pharmaceuticals. It is a protected amino acid derivative, where the tert-butyl group serves as a protecting group that can be removed under specific conditions. BOC-L-4-TERT-BUTYL-PHE is often used in peptide chemistry to introduce the amino acid phenylalanine into a peptide chain with protection from unwanted reactions. BOC-L-4-tert-butyl-Phe is widely utilized in the pharmaceutical industry for the production of various pharmaceutical compounds and is a vital building block in the synthesis of diverse peptide-based drugs.

InChI:InChI=1/C18H27NO4/c1-17(2,3)13-9-7-12(8-10-13)11-14(15(20)21)19-16(22)23-18(4,5)6/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 82372-74-5 (2S)-2-amino-3-(4-tert-butylphenyl)propanoic acid 

Downstream Products

• 949908-78-5 [2-(4-tert-butyl-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 949909-30-2 [2-(4-tert-butyl-phenyl)-1-formyl-ethyl]-carbamic acid tert-butyl ester 
• 949909-61-9 2-amino-N-[1-(4-tert-butyl-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethyl]-3-methyl-butyramide 
• 949909-62-0 5-[1,2]Dithiolan-3-yl-pentanoic acid {(S)-1-[(S)-1-(4-tert-butyl-benzyl)-2-ethylcarbamoyl-2-hydroxy-ethylcarbamoyl]-2-methyl-propyl}-amide 
• 545394-19-2 2-[(tert-butyl)oxycarbonyl]-7-(tert-butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 1378243-18-5 C₃₀H₄₉N₃O₆S 
• 1378243-28-7 C₂₆H₄₁N₃O₅S 

Relevant articles and documents

ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS

The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

CCK ANALOGS WITH APPETITE REGULATING ACTIVITY

The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.