143426-59-9

Basic information

• Product Name: 1-(3-Cyanobenzyl)imidazole
• Synonyms: 1-(3-Cyanobenzyl)imidazole
• CAS NO: 143426-59-9
• Molecular Formula: C₁₁H₉N₃
• Molecular Weight: 183.20926
• Mol File: 143426-59-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-Cyanobenzyl)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Cyanobenzyl)imidazole(143426-59-9)
• EPA Substance Registry System: 1-(3-Cyanobenzyl)imidazole(143426-59-9)

Safety Data

• Hazardous Substances Data: 143426-59-9(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains an imidazole ring linked to a cyanobenzyl group

Applications

a. Organic synthesis
b. Pharmaceutical research

Chemical reactions

a. Nucleophilic substitutions
b. Metal-catalyzed reactions

Reactivity

Unique structure and reactivity make it a valuable building block for the synthesis of complex organic compounds

Pharmacological properties

a. Potential antifungal activity
b. Potential antibacterial activity

Further research

Needed to fully understand its potential applications in the pharmaceutical industry

Upstream product

• 288-32-4 1H-imidazole 
• 28188-41-2 m-(bromomethyl)benzonitrile 

Downstream Products

• 135611-31-3 3-(1H-imidazol-1-ylmethyl)benzoic acid 
• 143426-62-4 ethyl 3-<(1H-imidazol-1-yl)methyl>benzoate 
• 139277-56-8 3-Imidazol-1-ylmethyl-benzoic acid hydrazide 
• 159148-87-5 C₁₁H₁₃N₃ 
• 1311939-56-6 N''-(3-(imidazol-1-yl)methylbenzyl)-N,N'-bis(tert-butoxycarbonyl)guanidine 

Relevant articles and documents

General base-guanidinium cooperation in bifunctional artificial phosphodiesterases

Artificial phosphodiesterases that combine a guanidinium unit with a general base connected by a m-xylylene linker catalyze the transesterification of the RNA model compound 2-hydroxypropyl p-nitrophenyl phosphate (HPNP). The bifunctional catalysts presented in this work show varying extents of cooperation between catalytic units and a rate enhancement of 4 ×10 4 in the most favorable case.

A structure-Permeability study of small drug-like molecules

A systematic structure-permeability relationship study on a set of small drug-like molecules with log D values in the range -2.5 to 3 and carrying a diverse array of functionality reveals that the compounds with log D>0 and 3 are highly permeable. Surprisingly, several tetrazole derivatives were found to be substrates for efflux pump(s).