143446-73-5 Usage
General Description
5-acetoxy-2-(R,S)butyryloxymethyl-1,3-oxathiolane, also known as sibutramine, is a synthetic compound that was formerly used as an appetite suppressant for the treatment of obesity. It works by inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the brain, leading to a feeling of fullness and a decreased appetite. However, due to concerns about its cardiovascular safety, sibutramine was withdrawn from the market in several countries. The compound is a controlled substance and its use is strictly regulated. Despite its potential for weight loss, the risks associated with its use have led to its limited availability and caution in its use.
Check Digit Verification of cas no
The CAS Registry Mumber 143446-73-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,4,4 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143446-73:
(8*1)+(7*4)+(6*3)+(5*4)+(4*4)+(3*6)+(2*7)+(1*3)=125
125 % 10 = 5
So 143446-73-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H16O5S/c1-3-4-8(12)13-5-10-15-9(6-16-10)14-7(2)11/h9-10H,3-6H2,1-2H3
143446-73-5Relevant articles and documents
Facile preparation of α-acyloxyacetaldehyde, a versatile intermediate in the synthesis of antiviral nucleosides
Du, Jinfa,Watanabe, Kyoichi A.
, p. 1925 - 1930 (2007/10/03)
This report describes a novel and simple method for the preparation of a versatile intermediate, α-acyloxyacetaldehyde and its acetals, and its application to the synthesis of 4-acetoxy-2-acyloxymethyl-1,3-oxathiolane, an important intermediate in the syn
Method of manufacture of 1,3-oxathiolane nucleosides
-
, (2008/06/13)
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.
