1434871-03-0

Basic information

• Product Name: (2,3-dihydroxy-4-methoxyphenyl)(2,4,5-trifluoro-3-methoxyphenyl)methanone
• Synonyms: (2,3-dihydroxy-4-methoxyphenyl)(2,4,5-trifluoro-3-methoxyphenyl)methanone
• CAS NO: 1434871-03-0
• Molecular Weight: 328.245
• Mol File: 1434871-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2,3-dihydroxy-4-methoxyphenyl)(2,4,5-trifluoro-3-methoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,3-dihydroxy-4-methoxyphenyl)(2,4,5-trifluoro-3-methoxyphenyl)methanone(1434871-03-0)
• EPA Substance Registry System: (2,3-dihydroxy-4-methoxyphenyl)(2,4,5-trifluoro-3-methoxyphenyl)methanone(1434871-03-0)

Safety Data

• Hazardous Substances Data: 1434871-03-0(Hazardous Substances Data)

Upstream product

• 1440-81-9 2,6-dimethoxyphenyl chloroacetate 
• 112811-65-1 3-methoxy-2,4,5-trifluorobenzoic acid 

Relevant articles and documents

Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin

With the aim of investigating the influence of fluorine, in particular on the A-ring, a new series of fluoro analogues (7a-l) of phenstatin (3) was synthesized and tested for interactions with tubulin polymerization and evaluated for cytotoxicity on an NCI-60 human cancer cell lines panel. We have shown that the replacement of 3,4,5-trimethoxyphenyl A-ring of phenstatin with 2,4,5-trifluoro-3-methoxyphenyl unit, results in the conservation of both antitubulin and cytotoxic effect. Fluoro isocombretastatin 7k was the most effective anticancer agent in the present study and demonstrated the highest antiproliferative potential on leukemia cell lines SR (GI50 = 15 nM) and HL-60(TB) (GI50 = 23 nM) and on melanoma cell line MDA-MB-435 (GI50 = 19 nM).