1435467-17-6Relevant articles and documents
Copper-catalyzed highly enantioselective cyclopentannulation of indoles with donor-acceptor cyclopropanes
Xiong, Hu,Xu, Hao,Liao, Saihu,Xie, Zuowei,Tang, Yong
supporting information, p. 7851 - 7854 (2013/06/27)
A highly diastereo- and enantioselective BOX/Cu(II)-catalyzed C2,C3-cyclopentannulation of indoles with donor-acceptor cyclopropanes has been developed on the basis of asymmetric formal [3 + 2] cycloaddition of indoles. This reaction provides rapid and facile access to a series of enantioenriched cyclopenta-fused indoline products and can be further extended to the construction of tetracyclic pyrroloindolines. The synthetic potential of the reaction was demonstrated in a four-step synthesis of the core structure of borreverine.