143558-00-3 Usage
Description
Rocuronium is a 5alpha-androstane compound with 3alpha-hydroxy, 17beta-acetoxy, 2beta-morpholino, and 16beta-N-allyllyrrolidinium substituents. It is a neuromuscular blocking agent used in medical procedures to induce muscle paralysis, particularly during surgery.
Uses
Used in Anesthesia:
Rocuronium is used as a neuromuscular blocking agent for facilitating endotracheal intubation and maintaining muscle relaxation during surgery. It works by binding to nicotinic acetylcholine receptors at the neuromuscular junction, thereby blocking the transmission of nerve impulses and causing muscle paralysis.
Used in Intensive Care Units (ICUs):
In the ICU setting, rocuronium is used as an adjunct to mechanical ventilation for patients who require prolonged muscle paralysis due to various medical conditions, such as severe brain injury, spinal cord injury, or respiratory failure. It helps to prevent patient-ventilator dyssynchrony and allows for better control of ventilation parameters.
Used in Emergency Medicine:
Rocuronium is utilized as a rapid-sequence intubation agent in emergency medicine to quickly induce muscle paralysis and facilitate endotracheal intubation in patients with life-threatening conditions, such as severe asthma, anaphylaxis, or traumatic injuries.
Used in Research:
In research settings, rocuronium is used as a tool to study the effects of neuromuscular blocking agents on muscle function and the mechanisms of action at the neuromuscular junction. This helps in understanding the pharmacology of these agents and developing new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 143558-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,5,5 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 143558-00:
(8*1)+(7*4)+(6*3)+(5*5)+(4*5)+(3*8)+(2*0)+(1*0)=123
123 % 10 = 3
So 143558-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35/h5,23-30,36H,1,6-21H2,2-4H3/q+1/t23?,24?,25?,26?,27-,28-,29-,30-,31-,32-/m0/s1
