143585-49-3

Basic information

• Product Name: (1R,2R)-N,N'-bis(2,4,6-triisopropylbenzenesulfonyl)-cyclohexane-1,2-diamine
• Synonyms: (1R,2R)-N,N'-bis(2,4,6-triisopropylbenzenesulfonyl)-cyclohexane-1,2-diamine
• CAS NO: 143585-49-3
• Molecular Weight: 647
• Mol File: 143585-49-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1R,2R)-N,N'-bis(2,4,6-triisopropylbenzenesulfonyl)-cyclohexane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-N,N'-bis(2,4,6-triisopropylbenzenesulfonyl)-cyclohexane-1,2-diamine(143585-49-3)
• EPA Substance Registry System: (1R,2R)-N,N'-bis(2,4,6-triisopropylbenzenesulfonyl)-cyclohexane-1,2-diamine(143585-49-3)

Safety Data

• Hazardous Substances Data: 143585-49-3(Hazardous Substances Data)

Upstream product

• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 591-87-7 Allyl acetate 
• 63877-57-6 2,4,6-tri(iso-propyl)benzenesulfonic acid 

Relevant articles and documents

MgBr2-promoted enantioselectIVe aryl addition of ArTi(OiPr)3 to ketones catalyzed by a titanium(IV) catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamine

MgBr2-promoted asymmetric addition of ArTi(OiPr)3 to ketones catalyzed by a titanium catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamines is reported, and results showed that the chiral N,N′-sulfonylated cyclohex

Reversal of enantioselectivity on protonation of enol(ate)s derived from 2-methyl-1-tetralone using C2-symmetric sulfonamides

The synthesis of enantiomerically enriched (R)-2-methyl-1-tetralone 1 (64% e.e.) was achieved through protonation of its lithium enolate 3 using a C 2-symmetrical bis-sulfonamide 5d as an internal proton source. Access to the complementary (S)-enantiomer 1 (45% e.e.) can be achieved using an external quench strategy involving acetic acid as the external proton source.

A Catalytic Enantioselective Reaction Using a C2-Symmetric Disulfonamide as a Chiral Ligand: Alkylation of Aldehydes Catalyzed by Disulfonamide-Ti(O-i-Pr)4-Dialkyl Zinc System

Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed.This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide.The chiral Lewis acid catalysts used in the present study are the titanium complexes, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.Key Words: Chiral disulfonamide; chiral titanium complex; enantioselective alkylation; dialkyl zinc; catalytic reaction