143655-57-6

Basic information

• Product Name: 5-Acetylamino-7-fluoro-8-methyl-1,2,3,4-tetrahydro-naphthalene
• CAS NO: 143655-57-6
• Molecular Weight: 221.275
• Mol File: 143655-57-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 361.9±42.0 °C(Predicted)
• Density: 1.165±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-Acetylamino-7-fluoro-8-methyl-1,2,3,4-tetrahydro-naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetylamino-7-fluoro-8-methyl-1,2,3,4-tetrahydro-naphthalene(143655-57-6)
• EPA Substance Registry System: 5-Acetylamino-7-fluoro-8-methyl-1,2,3,4-tetrahydro-naphthalene(143655-57-6)

Safety Data

• Hazardous Substances Data: 143655-57-6(Hazardous Substances Data)

Upstream product

• 108-20-3 di-isopropyl ether 
• 182182-29-2 5-acetylamino-7-fluoro-8-methyl-1-tetralone 
• 7440-44-0 pyrographite 
• 143655-55-4 methyl 4-(4-fluoro-3-methyl-6-nitrophenyl)butanoate 
• 210346-38-6 4-(4-fluoro-5-methyl-2-nitrophenyl)butyric acid 
• 143655-56-5 7-Fluoro-8-methyl-5-nitro-1-tetralone 
• 143655-54-3 methyl 4-(4-fluoro-3-methylphenyl)butanoate 
• 331-43-1 4-(4-fluoro-3-methyl-phenyl)-butyric acid 
• 108-24-7 acetic anhydride 
• 210346-65-9 8-amino-6-fluoro-5-methyl-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 143655-58-7 8-Acetylamino-6-fluoro-5-methyl-1-tetralone 

Relevant articles and documents

Aminotetralone derivatives and preparation process thereof

The present invention pertains to a process for the preparation of Compound (4) through the below-described reaction route: STR1 wherein R1 and R2 each represents H, halogen, OH or C1-6 alkyl group; X and Y each represents a protected amino group and n stands for 0 to 4. According to the above process, an aminotetralone derivative which is an intermediate useful for an industrial preparation of a camptothecin derivative can be obtained in a convenient manner and in a high yield.

Hexa-cyclic compound

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: STR1 The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.