14366-96-2Relevant articles and documents
Stereoselective Addition of Organoaluminium or Organomanganese Reagents to 2-Methyl-3-oxo Amides (or Esters) Providing erythro or threo 2-Methyl-3-hydroxy Amides (or Esters)
Taniguchi, Masahiko,Fujii, Hideaki,Oshima, Koichiro,Utimoto, Kiitiro
, p. 4353 - 4356 (1992)
Treatment of 2-methyl-3-oxo amides or 2-methyl-3-oxo esters with trialkylaluminium or alkylmanganese halide provided the corresponding erythro (or threo) 3-hydroxy-2-methyl amides or 3-hydroxy-2-methyl esters with high stereoselectivity.
Highly diastereo- and enantioselective copper-catalyzed domino reduction/aldol reaction of ketones with methyl acrylate
Deschamp, Julia,Chuzel, Olivier,Hannedouche, Jerome,Riant, Olivier
, p. 1292 - 1297 (2007/10/03)
(Chemical Equation Presented) A good choice: A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper-catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ke
Internal Lewis acid coordination as a powerful tool to promote highly stereoselective alkylation of α-alkyl-β-hydroxy ketones with Grignard reagents
Bartoli, Giuseppe,Bellucci, M. Cristina,Bosco, Marcella,Marcantoni, Enrico,Sambri, Letizia
, p. 2154 - 2161 (2007/10/03)
An efficient and highly diastereoselective protocol is described for the alkylation of β-hydroxy ketones that contain an α-stereocenter. This method is based on the preliminary transformation of the β-hydroxy group into a titanium alcoholate by means of t