143673-67-0

Basic information

• Product Name: (3R,6S)-<6-2H>-6-benzyloxymethyl-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine
• CAS NO: 143673-67-0
• Molecular Weight: 305.381
• Mol File: 143673-67-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R,6S)-<6-2H>-6-benzyloxymethyl-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,6S)-<6-2H>-6-benzyloxymethyl-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine(143673-67-0)
• EPA Substance Registry System: (3R,6S)-<6-2H>-6-benzyloxymethyl-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazine(143673-67-0)

Safety Data

• Hazardous Substances Data: 143673-67-0(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 143673-65-8 <6-2H2>-(3R)-3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazine 
• 17690-16-3 benzyl bromomethyl ether 

Downstream Products

• 4070-48-8 D-Valine methyl ester 
• 143687-03-0 (2S)-<2-2H>-O-benzylserine methyl ester 

Relevant articles and documents

Stereospecific Synthesis of α-Deuteriated α-Amino Acids: Regiospecific Deuteriation of Chiral 3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazines

Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazines in refluxing CH3O2H-2H2O gives the -isotopomer in excellent yields without disturbing the stereogenic centre at C-3.These compounds provide convenient and efficient access to a range of (R)- and (S)-α-deuteriated α-amino acids, including serine, aspartic acid, allylglycine and phenylalanine, via alkylation of the butyllithium generated C-6 anion.