1436865-13-2

Basic information

• Product Name: C₂₂H₂₇Cl₂N₃O₂
• CAS NO: 1436865-13-2
• Molecular Weight: 436.381
• Mol File: 1436865-13-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₇Cl₂N₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₇Cl₂N₃O₂(1436865-13-2)
• EPA Substance Registry System: C₂₂H₂₇Cl₂N₃O₂(1436865-13-2)

Safety Data

• Hazardous Substances Data: 1436865-13-2(Hazardous Substances Data)

Upstream product

• 251552-34-8 4-(3-piperidin-1-ylpropoxy)phenylamine 
• 54730-35-7 3,5-dichloro-4-methylaniline 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (Part I)

A series of structurally novel aryl ureas was derived from optimization of the HTS lead as selective histamine H3 receptor (H3R) antagonists. The SAR was explored and the data obtained set up the starting point and foundation for further optimization. The most potent tool compounds, as exemplified by compounds 2l, 5b, 5d, and 5e, displayed antagonism potencies in the subnanomolar range in in vitro human-H3R FLIPR assays and rhesus monkey H3R binding assays.