143706-79-0Relevant articles and documents
Nucleophilic reactions of ethyl (Z)-2?bromo-4,4,4-trifluorobut-2-enoate: One molecule – various heterocycles
Kobelevskaya, Valentina A.,Rulev, Alexander Yu.,Tyumentsev, Ilya A.,Ushakov, Igor A.
supporting information, (2022/01/03)
The synthetic approach to different fluorinated heterocycles based on ethyl (Z)-2?bromo-4,4,4-trifluorobut-2-enoate and binucleophiles is described. The assembly of all heterocyclic structures proceeds through the formation of the product of conjugate nucleophilic addition as a key step.
Cyclocondensation of Alkylhydrazines and β-Substituted Acetylenic Esters: Synthesis of 3-Hydroxypyrazoles
Hamper, Bruce C.,Kurtzweil, Mitchell L.,Beck, James P.
, p. 5680 - 5686 (2007/10/02)
Addition of monosubstituted alkylhydrazines to acetylenic esters with either electron-withdrawing or sterically bulky β-substituents afforded 1-alkyl-3-hydroxy-5-substituted-pyrazoles 1 as the major regioisomeric product.By comparison, the classical cyclo
