14377-63-0

Basic information

• Product Name: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)
• Synonyms: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI);1-phenyl-2-(piperidin-1-yl)ethane-1,2-dione;1-phenyl-2-(piperidin-1-yl)ethane-1,2-dione(WXC04924)
• CAS NO: 14377-63-0
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.2637
• Product Categories: Methylphenidate
• Mol File: 14377-63-0.mol
• Article Data: 95

Chemical Properties

• Melting Point: 107-108 °C
• Boiling Point: 343.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• PKA: -1.36±0.20(Predicted)
• CAS DataBase Reference: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(14377-63-0)
• EPA Substance Registry System: 1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- Piperidine, 1-(oxophenylacetyl)- (9CI)(14377-63-0)

Safety Data

• Hazardous Substances Data: 14377-63-0(Hazardous Substances Data)

Usage

General Description

1,2-Ethanedione, 1-phenyl-2-(1-piperidinyl)- is a chemical compound used in the synthesis of pharmaceuticals and organic compounds. It is a piperidine derivative that has been studied for its potential analgesic and anesthetic properties. Piperidine, 1-(oxophenylacetyl)- (9CI), also known as phenacetyl piperidine, is an organic compound with potential anticonvulsant and anti-inflammatory properties. It is used in the synthesis of various pharmaceuticals and research chemicals. Both chemicals have potential applications in the pharmaceutical industry and in the development of new therapeutic agents.

Upstream product

• 110-89-4 piperidine 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 108-86-1 bromobenzene 
• 201230-82-2 carbon monoxide 
• 591-50-4 iodobenzene 
• 1074-12-0 phenylglyoxal hydrate 
• 779-52-2 1-phenyl-2-piperidin-1-yl-ethanone 
• 17506-94-4 1-<(piperidin-1-ylcarbonyl)carbonyl>piperidine 
• 591-51-5 phenyllithium 
• 666749-77-5 methyl 2-(2,2-diphenyl-3,3-dichloroaziridin-1-yl)-2-phenylacetate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 3626-62-8 2-phenyl-1-(1-piperidinyl)ethanone 
• 13665-04-8 2,2-dibromoacetophenone 
• 4636-16-2 iodoacetophenone 

Downstream Products

• 95683-48-0 N-<α-(piperidinocarbonyl)benzylidene>trimethylsilylmethylamine 
• 109894-09-9 1,1,6,6-Tetraphenyl-hexa-2,4-diyne-1,6-diol; compound with 1-phenyl-2-piperidin-1-yl-ethane-1,2-dione 
• 113397-24-3 Biphenyl-2,2'-dicarboxylic acid bis-dicyclohexylamide; compound with 1-phenyl-2-piperidin-1-yl-ethane-1,2-dione 
• 102423-80-3 2-hydroxy-2-phenyl-1-(piperidin-1-yl)ethan-1-one 
• 21675-04-7 (6S,7R)-7-Hydroxy-7-phenyl-1-aza-bicyclo[4.2.0]octan-8-one 
• 219915-67-0 4-methyl-N’-(2-oxo-1-phenyl-2-(piperidin-1-yl)ethylidene)benzenesulfono hydrazide 
• 95683-53-7 5-Phenyl-5-(piperidine-1-carbonyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 95683-52-6 (1S,3aS,6aR)-1-Phenyl-1-(piperidine-1-carbonyl)-hexahydro-cyclopenta[c]pyrrol-4-one 
• 95683-51-5 (2S,3R)-2-Phenyl-2-(piperidine-1-carbonyl)-pyrrolidine-3-carbonitrile 
• 95709-93-6 (3R,5S)-5-Phenyl-5-(piperidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 95709-93-6 (3S,5S)-5-Phenyl-5-(piperidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 95683-49-1 (2S,3R)-2-Phenyl-2-(piperidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 95683-49-1 (2S,3S)-2-Phenyl-2-(piperidine-1-carbonyl)-pyrrolidine-3-carboxylic acid methyl ester 
• 95683-54-8 2-{[2-Oxo-1-phenyl-2-piperidin-1-yl-eth-(E)-ylideneamino]-methyl}-succinic acid dimethyl ester 

Relevant articles and documents

Mesoporous poly-melamine-formaldehyde stabilized palladium nanoparticle (Pd@mPMF) catalyzed mono and double carbonylation of aryl halides with amines

A new mesoporous poly-melamine-formaldehyde material supported Pd nano catalyst (mPMF-Pd0) has been synthesized and characterized by thermogravimetric analysis (TGA), powder X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflection spectroscopy (DRS), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and a N2 adsorption study. The mPMF-Pd0 material showed very good catalytic activity in the field of mono and double amino carbonylation of aryl bromides/iodides. Moreover, the catalyst is easily recoverable and can be reused six times without appreciable loss of catalytic activity in the above reactions. So, the highly dispersed and strongly bound palladium(0) sites in the mPMF-Pd0 could be responsible for the observed high activities. Due to strong binding with the functional groups of the polymer, no evidence of leached Pd from the catalyst during the course of reaction occurred, suggesting true heterogeneity in the catalytic process. This journal is

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Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides

The amino dicarbonylation of aryl halides affording α-ketoamides with Pd catalysts is highly dependent on the stereoelectronic properties of the involved ligands. Ionic diphosphine ligand L4 can serve as precursor of a hemilabile P,C (phosphine, carbene)-hybrid ligand to form a stable Pd(II)-complex, Pd-L4. In contrast, analogues L1-L3 with a similar 1-(thiophen-3-yl)-benzimidazolyl skeleton behave as typical (mono/di)phosphines. The catalytic system resulting from the complexation of PdCl2(MeCN)2 and L4 exhibits good catalytic performance in terms of aryl iodides conversion (81-95%) and α-ketoamide selectivity (80-91%), as well as the available recyclability in the RTIL of [Bpy]BF4. The in situ FT-IR analysis reveals that the PdCl2(MeCN)2-L4 catalytic system favors the amino dicarbonylation toward α-ketoamides according to the proposed mechanism of cycle I, which involves two independent CO-insertion steps.

Diversification of α-ketoamides: Via transamidation reactions with alkyl and benzyl amines at room temperature

A wide range of N-tosyl α-ketoamides underwent transamidation with various alkyl amines in the absence of a catalyst, base, or additive. On the other hand, transamidation in N-Boc α-ketoamides was achieved in the presence of Cs2CO3. The reactions proceede