143770-57-4

Basic information

• Product Name: N-((5-bromopyridin-3-yl)methyl)-4-methoxyaniline
• CAS NO: 143770-57-4
• Molecular Weight: 293.163
• Mol File: 143770-57-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-((5-bromopyridin-3-yl)methyl)-4-methoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-((5-bromopyridin-3-yl)methyl)-4-methoxyaniline(143770-57-4)
• EPA Substance Registry System: N-((5-bromopyridin-3-yl)methyl)-4-methoxyaniline(143770-57-4)

Safety Data

• Hazardous Substances Data: 143770-57-4(Hazardous Substances Data)

Upstream product

• 37669-64-0 (5-bromopyridin-3-yl)methanol 
• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 104-94-9 4-methoxy-aniline 
• 39741-46-3 3-bromo-5-(chloromethyl)-pyridine hydrochloride 

Relevant articles and documents

KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE

Disclosed herein are kinase inhibitor compounds having structure (I), or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, X, Y, Z, and (AA) are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.

Preparation of Benzonaphthyridines

A divergent synthesis of substituted benzonaphthryridines 5a-h is described, which features an intramolecular pyridine cyclization step as the key reaction.The pyridine precursors are conveniently prepared from the pyridinium hydrochloride 2 and the requisite anilines.Cyclization of the non-symmetric substrates 3e and 3f did not proceed with significant regioselectivity.