143773-73-3

Basic information

• Product Name: Benzaldehyde, 4-[(10-bromodecyl)oxy]-
• CAS NO: 143773-73-3
• Molecular Formula: C17H25BrO2
• Molecular Weight: 341.288
• Mol File: 143773-73-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[(10-bromodecyl)oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[(10-bromodecyl)oxy]-(143773-73-3)
• EPA Substance Registry System: Benzaldehyde, 4-[(10-bromodecyl)oxy]-(143773-73-3)

Safety Data

• Hazardous Substances Data: 143773-73-3(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 4101-68-2 1,10-dibromodecane 
• 62443-10-1 methyl 4-decyloxybenzoate 

Downstream Products

• 88931-97-9 p-(ω-bromodecyloxy)benzoic acid 
• 1416691-53-6 4-(10-azidodecyloxy)benzaldehyde 
• 1620155-59-0 C₂₆H₄₄BrNO₃ 

Relevant articles and documents

A novel selective mitochondrial-targeted curcumin analog with remarkable cytotoxicity in glioma cells

Naturally occurring polyphenol curcumin (4) or demethoxycurcumin (5) and their synthetic derivatives display promising anticancer activities. However, their further development is limited by low bioavailability and poor selectivity. Thus, a mitochondria-targeted compound 14 (DMC-TPP) was prepared in the present study by conjugating a triphenylphosphine moiety to the phenolic hydroxyl group of demethoxycurcumin to enhance its bioavailability and treatment efficacy. The in vitro biological experiments of DMC-TPP showed that it not only displayed higher cytotoxicity as compared with its parent compound 5, but also exhibited superior mitochondria accumulation ability. Glioma cells were more sensitive to DMC-TPP, which inhibited the proliferation of U251 cells with an IC50 of 0.42 μM. The mechanism studies showed that DMC-TPP triggers mitochondria-dependent apoptosis, caused by caspase activation, production of reactive oxygen species (ROS) and decrease of mitochondrial membrane potential (MMP). In addition, DMC-TPP efficiently inhibited cellular thioredoxin reductase, which contributed to its cytotoxicity. Significantly, DMC-TPP delayed tumor progression in a mouse xenograft model of human glioma cancer. Taken together, the potent in vitro and in vivo antitumor activity of DMC-TPP warrant further comprehensive evaluation as a novel anti-glioma agent.

A highly efficient artificial light-harvesting system with two-step sequential energy transfer based on supramolecular self-assembly

A highly efficient artificial light-harvesting system (ALHS) in the aqueous phase with a two-step sequential energy transfer process has been successfully constructed based on the host-guest interaction between a water-soluble pillar[5]arene (WP5) and a b

Governing the DNA-binding mode of styryl dyes by the length of their alkyl substituents-from intercalation to major groove binding

A series of monomeric and homodimeric 4-alkoxystyryl(pyridinium) dyes was synthesized and their DNA-binding properties were investigated. We found that the length of the alkyl substituent has a crucial influence on the binding mode of the dyes, although t