1437786-93-0

Basic information

• Product Name: 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine
• Synonyms: 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine
• CAS NO: 1437786-93-0
• Molecular Weight: 421.788
• Mol File: 1437786-93-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine(1437786-93-0)
• EPA Substance Registry System: 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine(1437786-93-0)

Safety Data

• Hazardous Substances Data: 1437786-93-0(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 104-86-9 4-chlorobenzylamine 
• 29421-75-8 3-bromo-2-methyl-5-thiophenecarboxyaldehyde 
• 212392-65-9 [(4-chlorophenyl)methyl](3-pyridinylmethyl)amine 

Relevant articles and documents

Optimized chemical probes for REV-ERBα

REV-ERBα has emerged as an important target for regulation of circadian rhythm and its associated physiology. Herein, we report on the optimization of a series of REV-ERBα agonists based on GSK4112 (1) for potency, selectivity, and bioavailability.(1) Potent REV-ERBα agonists 4, 10, 16, and 23 are detailed for their ability to suppress BMAL and IL-6 expression from human cells while also demonstrating excellent selectivity over LXRα. Amine 4 demonstrated in vivo bioavailability after either iv or oral dosing.