1438-58-0 Usage
Description
(2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is a complex organic compound characterized by a spiro-fused furan and naphthalene ring system. It features a methyl ester group attached to the acetic acid moiety and is optically active due to the specific orientation of its stereocenters at the 2 and 5 positions. (2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is heavily substituted with methyl groups at various positions, which contributes to its overall structural complexity. This unique structure and properties may endow it with potential applications in drug discovery, material science, and other fields.
Uses
Used in Drug Discovery:
(2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is used as a potential candidate in drug discovery for its unique structure and properties that may offer novel therapeutic effects and mechanisms of action.
Used in Material Science:
In the field of material science, (2R,5S)-4,4'aα,5,5',6',7',8',8'a-Octahydro-2',5,5',5',8'aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetic acid methyl ester is utilized for its potential to contribute to the development of new materials with specific characteristics, such as improved stability, reactivity, or selectivity in various chemical processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1438-58-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,3 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1438-58:
(6*1)+(5*4)+(4*3)+(3*8)+(2*5)+(1*8)=80
80 % 10 = 0
So 1438-58-0 is a valid CAS Registry Number.
1438-58-0Relevant articles and documents
Derivatives of grindelic acid: From a non-active natural diterpene to synthetic antitumor derivatives
Reta, Guillermo F.,Chiaramello, Alejandra I.,Garcia, Celina,Leon, Leticia G.,Martin, Victor S.,Padron, Jose M.,Tonn, Carlos E.,Donadel, Osvaldo J.
, p. 28 - 38 (2013/10/01)
Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as cytotoxic agents against a panel of five human solid tumor cell lines (HBL-100, HeLa, SW1573, T-47D, and WiDr). The presence of the diamide functionalizations enhanced the cytotoxic effect. N-Benzyl-N-(1-(benzylamino)-2-methyl-1-oxopropan-2-yl)grindelicamide, proved to be the most active product in all cell lines tested, with values of 0.95 (±0.38) μM against HBL-100 cells. 2013 Elsevier Masson SAS. All rights reserved.
Stereoselective Synthesis of the Novel Bisnorditerpene Grindelistrictic Acid, Isolated from Grindelia stricta
Olivieri, Alejandro C.,Gonzalez-Sierra, Manuel,Ruveda, Edmundo A.
, p. 2824 - 2826 (2007/10/02)
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