1438263-83-2

Basic information

• Product Name: (S)-N,N,3,3-tetramethyl-N-(4-bromobenzyl)-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium bromide
• Synonyms: (S)-N,N,3,3-tetramethyl-N-(4-bromobenzyl)-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium bromide
• CAS NO: 1438263-83-2
• Molecular Weight: 574.38
• Mol File: 1438263-83-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-N,N,3,3-tetramethyl-N-(4-bromobenzyl)-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,N,3,3-tetramethyl-N-(4-bromobenzyl)-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium bromide(1438263-83-2)
• EPA Substance Registry System: (S)-N,N,3,3-tetramethyl-N-(4-bromobenzyl)-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium bromide(1438263-83-2)

Safety Data

• Hazardous Substances Data: 1438263-83-2(Hazardous Substances Data)

Upstream product

• 2131-61-5 p-nitrophenyl isothiocyanate 
• 874348-14-8 (S)-N¹,N¹,3,3- tetramethylbutane-1,2-diamine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 198422-08-1 L-tert-leucine N,N-dimethylamide 
• 340161-34-4 (S)-tert-butyl 1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 

Relevant articles and documents

L-tert-Leucine derived urea-ammonium salts: Efficient bifunctional phase transfer catalysts for highly diastereo- and enantioselective aza-Henry reaction of isatin-derived N-Boc ketimines with α-aryl nitromethanes

An efficient way of aza-Henry reaction between isatin-derived N-Boc ketimines and α-aryl nitromethanes catalyzed by bifunctional phase transfer catalysts with a quaternary ammonium center derived from L-tert-Leucine has been developed. A series of 3-substituted 3-amino-oxindoles were constructed by this catalytic protocol in excellent yields (90–99%), with high enantioselectivities (83–95%)and diastereoselectivities (79:21–97:3). The asymmetric aza-Henry reaction of N-Boc amidosulfones and α-aryl nitromethanes were also investigated and gave the corresponding products in high to excellent yields (72–97%)with high enantioselectivities (up to 99%)and diastereoselectivities (up to >99:1).