143840-02-2Relevant articles and documents
Peptide-nucleoside conjugates: Synthesis and anti-HIV activities
Mourier,Trabaud,Graciet,Simon,Niddam,Faury,Charvet,Camplo,Chermann,Kraus
, p. 1393 - 1402 (1995)
New peptide-nucleosides which consist of an anti-RT nucleoside and anti- protease peptide moieties, were designed in order to investigate their anti- HIV-1 properties. The synthesis of these new analogues was achieved using BOP coupling reagent which avoided the protection and deprotection steps of the 5'-OH group of the nucleoside part. These new compounds tested on MT4 infected cells show no increase in anti-HIV activities compared to that of the component pieces. Interestingly we found that the 5'-(tert- butyldiphenyl)silyl analogues show anti-HIV activities equivalent to that of the 5'-free OH corresponding compounds. This result suggests a possible interaction of these compounds at a non-substrate binding site of the reverse transcriptase.
