14387-18-9Relevant articles and documents
SUBSTITUTED HETEROCYCLIC COMPOUNDS
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Page/Page column 102, (2010/10/03)
The present invention relates to substituted heterocyclic compounds of Formula I or XI: or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine II4 receptor inhibitors useful in the treatment of histamine II4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.
Simple synthesis of arylsuccinic acids
Makosza,Marcinowicz
, p. 1311 - 1312 (2007/10/03)
Alkylation of arylacetonitriles with potassium chloroacetate proceeds selectively leading to 3-cyano-3-arylpropionic acids, which are directly hydrolyzed to arylsuccinic acids.