143874-13-9

Basic information

• Product Name: 3,4-DIFLUOROPHENYLACETYLENE
• Synonyms: 3,4-DIFLUOROPHENYLACETYLENE;4-ETHYNYL-1,2-DIFLUORO-BENZENE;Benzene, 4-ethynyl-1,2-difluoro- (9CI);3,4-Difluorophenylacetylene95%;Benzene, 4-ethynyl-1,2-difluoro-;1,2-Difluoro-4-ethynylbenzene;3,4-Difluoro-1-ethynylbenzene
• CAS NO: 143874-13-9
• Molecular Formula: C₈H₄F₂
• Molecular Weight: 138.11
• Product Categories: Aromatics
• Mol File: 143874-13-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 54/2mm
• Flash Point: 7 °C
• Appearance: /
• Density: 1.144 g/mL at 25 °C
• Vapor Pressure: 5.998mmHg at 25°C
• Refractive Index: 1.4902
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,4-DIFLUOROPHENYLACETYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIFLUOROPHENYLACETYLENE(143874-13-9)
• EPA Substance Registry System: 3,4-DIFLUOROPHENYLACETYLENE(143874-13-9)

Safety Data

• Hazard Codes: F
• Statements: 11
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 143874-13-9(Hazardous Substances Data)

Usage

Description

3,4-DIFLUOROPHENYLACETYLENE is an organic compound characterized by the presence of a triple bond between two carbon atoms (acetylene) and a phenyl ring with two fluorine atoms at the 3rd and 4th positions. It is a versatile building block in the field of organic synthesis, known for its unique chemical properties and reactivity.

Uses

Used in Organic Synthesis:
3,4-DIFLUOROPHENYLACETYLENE is used as a fundamental building block for the preparation of various complex organic molecules. Its unique structure allows for a wide range of applications in the synthesis of different compounds.
Used in Pharmaceutical Industry:
3,4-DIFLUOROPHENYLACETYLENE is used as a key intermediate in the synthesis of metalated and metal-free tetraalkynyl-substituted phthalocyanines. These compounds have potential applications in the development of new drugs, particularly in the fields of cancer treatment and imaging technologies.
Used in Chemical Industry:
In the chemical industry, 3,4-DIFLUOROPHENYLACETYLENE is utilized for the preparation of 3,5-substituted enones, which are important intermediates in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.
Overall, 3,4-DIFLUOROPHENYLACETYLENE plays a crucial role in the development of new materials and compounds across various industries, particularly in the pharmaceutical and chemical sectors, due to its unique chemical properties and reactivity.

InChI:InChI=1/C8H4F2/c1-2-6-3-4-7(9)8(10)5-6/h1,3-5H

Upstream product

• 866683-38-7 [2-(3,4-difluorophenyl)ethynyl]trimethylsilane 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 159957-01-4 3,4-Difluoro-β,β'-dibromostyrene 
• 34036-07-2 3,4 difluorobenzaldehyde 

Downstream Products

• 177577-65-0 1-(3,4-difluorophenyl)-2-[4-(1-trans-pentenyl)phenyl]acetylene 
• 326795-66-8 2-propyl-7-(3,4-difluorophenylethynyl)fluorene 
• 326795-85-1 2-propyl-7-(3,4-difluorophenylethynyl)phenanthrene 
• 1198354-56-1 5-(3,4-difluorophenyl)-3-(pyridin-3-yl)isoxazole 
• 1272632-70-8 4-(3,4-difluorophenyl)-2-methylenebut-3-yn-1-ol 
• 1286239-82-4 3-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]propyl 2,4,4,4-tetrachloro-2-methylbutanoate 
• 1286239-77-7 3-[4-(3,4-difluorophenyl)-1H-1,2,3-triazol-1-yl]propyl methacrylate 
• 1312797-57-1 C₁₆H₁₄F₂O 
• 1245447-39-5 C₁₆H₆F₄ 
• 1374219-62-1 5-(3,4-difluorobenzyl)-3-(3,4-difluorophenyl)isoxazole 
• 1377273-65-8 C₃₁H₂₇ClF₂N₆O₃ 
• 1377273-41-0 (1S,2R,3S,4R,5S)-4-(2-((3,4-difluorophenyl)ethynyl)-6-(methylamino)-9H-purin-9-yl)-2,3-O-isopropylidene-N-methylbicyclo[3.1.0]hexane-1-carboxamide 
• 1373495-88-5 C₁₆H₁₀F₂O₃ 
• 1373498-48-6 C₁₆H₁₀F₂O₄ 

Relevant articles and documents

Discovery and Characterization of Pure RhlR Antagonists against Pseudomonas aeruginosa Infections

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic human pathogen that forms biofilms and produces virulence factors via quorum sensing (QS). Blocking the QS system in P. aeruginosa is an excellent strategy to reduce biofilm formation and the production of virulence factors. RhlR plays an essential role in the QS system of P. aeruginosa. We synthesized 55 analogues based on the chemical structure of 4-gingerol and evaluated their RhlR inhibitory activities using the cell-based reporter strain assay. Comprehensive structure-activity relationship studies identified the alkynyl ketone 30 as the most potent RhlR antagonist. This compound displayed selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation, and reduced production of virulence factors in P. aeruginosa. Furthermore, the survival rate of Tenebrio molitor larvae treated with 30 in vivo greatly improved. Therefore, compound 30, a pure RhlR antagonist, can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections.

PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C1-C4 alkyl, C1-C4 alkoxy, C1-C5 acyl, halo, amino, nitro, cyano, hydroxy, C1-C5 acylamino, C1-C4 alkylsulfonylamino, mono-, di- or trifluorinated C1-C3 alkyl, substituents which may be the same or different and may bear a CONH2, CONHCH3, CON(CH3)2, CO2H, CO2CH3, OCF3, CH2NHCOCH3, CH2NH2, CH2N(CH3)2, CH2CN, CH2OH, CH2NHSO2CH3, CH2N(CH3)(CH2)2 CN, CH2N(CH3)CH(CH3)2, CH2NHCH(CH3)2, CH2NH(CH2)2CH3, CH2NHCO2R4, CH2NHCH2CH3, CH2NHCH3 NHCOC(CH3)2, or N(S(O)2CH3)2 substituent; R1 is hydrogen, halo, R4, CN, C(NOH)R3, C(NO-R4)R3, (CH)2CO2R4 , (CH2)n OR3 , COR3 , CF3,SR4 , S(O)R4, S(O)2R4, COCH2CO2R3 , NHSO2R4 , NHCOR3, C(NOR3)NH2, CH2OCOR3,(CH2)n NH2, CON(CH3)2 (CH2)nNHCO2R4 , CO2R3, CONH2, CSNH2, C(NH)NHOR3, (CH2)nN(CH3)2, or CONHNHCOR3; R2 is 1,2-ethenediyl or 1,2-ethynediyl; R3 is hydrogen or C1-C4 alkyl; R4 is C1-C4 alkyl; and n is 0, 1, 2,3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.