143883-61-8Relevant articles and documents
Regiospecific Michael Additions with 2-Aminopurines
Geen, Graham R.,Kincey, Peter M.,Choudary, Bernadette M.
, p. 4609 - 4612 (1992)
N-9 alkylated materials are the sole products obtained from extended reaction of 2-aminopurines (potential guanine precursors) with Michael acceptors.This was used as the basis for a highly regioselective synthesis of famciclovir, the oral form of the anti-herpesvirus agent penciclovir. Key Words: Michael addition; 2-aminopurines; regiospecific; famciclovir; penciclovir.