143979-15-1

Basic information

• Product Name: Boc-L-2-allylglycine dicyclohexylamine salt
• Synonyms: (S)-2-(Boc-amino)-4-pentenoic acid(dicyclohexylammonium) salt;Boc-L-2-allylglycine(dicyclohexylammonium) salt;(S)-N-BOC-alpha-Allylglycine dicyclohexylamine salt, 98% ee, 98%;2-Allyl-N-Boc-L-glycine dicyclohexylaMine salt, 95%;Boc-L-Allyglycine·DCHA Boc-L-Allyglycine·DCHA;(S)-N-BOC-alpha-Allylglycine dicyclohexylaMine salt, 98%, 98% ee;(S)-2-Boc-AMino-4-pentenoic acid with N-cyclohexylcyclohexanaMine salt;dicyclohexylammonium 2-((tert-butoxycarbonyl)amino)pent-4-enoate
• CAS NO: 143979-15-1
• Molecular Formula: C₁₀H₁₇NO₄*C₁₂H₂₃N
• Molecular Weight: 396.56
• Product Categories: Amino Acids;Unusual amino acids;Amino Acid Derivatives;a-amino
• Mol File: 143979-15-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 352 °C at 760 mmHg
• Flash Point: 166.7 °C
• Appearance: White to pale yellow/Powder
• Density: 1.108g/cm³
• Vapor Pressure: 7.54E-05mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: Boc-L-2-allylglycine dicyclohexylamine salt(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-2-allylglycine dicyclohexylamine salt(143979-15-1)
• EPA Substance Registry System: Boc-L-2-allylglycine dicyclohexylamine salt(143979-15-1)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 143979-15-1(Hazardous Substances Data)

Usage

Description

Boc-L-2-allylglycine dicyclohexylamine salt is a white powder pharmaceutical intermediate with significant applications in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
Boc-L-2-allylglycine dicyclohexylamine salt is used as a pharmaceutical intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and therapies.

InChI:InChI=1/C10H17NO4/c1-5-6-11(7-8(12)13)9(14)15-10(2,3)4/h5H,1,6-7H2,2-4H3,(H,12,13)

Upstream product

• 1069-48-3 rac-allylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 106928-50-1 methyl 2-[(tert-butoxycarbonyl)amino]pent-4-enoate 
• 123457-13-6 p-nitrobenzyl (2S*,5R*,7S*)-7-<<(1,1-dimethylethoxy)carbonyl>amino>-8-oxo-4-thia-1-azabicyclo<3.3.0>octane-2-carboxylate 
• 123468-22-4 (6S,7aR)-6-tert-Butoxycarbonylamino-5-oxo-5,6,7,7a-tetrahydro-pyrrolo[2,1-b]thiazole-3-carboxylic acid 4-nitro-benzyl ester 
• 123457-14-7 (3R,6R,7aS)-2-Benzoyloxy-6-tert-butoxycarbonylamino-5-oxo-hexahydro-pyrrolo[2,1-b]thiazole-3-carboxylic acid 4-nitro-benzyl ester 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 89985-87-5 methyl (2S)-2-tert-butoxycarbonylamino-4-pentenoate 

Relevant articles and documents

MOLECULAR MODELING OF γ-LACTAM ANALOGUES OF β-LACTAM ANTIBACTERIAL AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION OF SELECTED PENEM AND CARBAPENEM ANALOGUES

Computational chemistry made possible the prediction of the three-dimensional structures of γ-lactam analogues of penems and carbapenems before the analogues were made.Molecular superpositioning showed that these novel structures with a 7β-acylamino side-chain present the pharmacophoric groups in close spatial similarity to the groups in biologically active cephalosporin and penicillin antibiotics.This suggest that 8-oxo-7-acylamino-1-azabicyclooct-2-ene-2-carboxylates and 4-thia-analogues can be accommodated in the same active sites of essential bacterical penicillin-binding proteins where cephalosporins and penicillins are recognized.The syntheses of these compounds are reported.The γ-lactams exhibit low, but detectable levels of antibacterial activity and suggest promise that substantial activity can be achieved with other γ-lactams.