1440419-50-0

Basic information

• Product Name: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate
• Synonyms: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate
• CAS NO: 1440419-50-0
• Molecular Weight: 507.694
• Mol File: 1440419-50-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate(1440419-50-0)
• EPA Substance Registry System: S-phenyl [(7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl)methyl](4-methoxybenzyl)carbamothioate(1440419-50-0)

Safety Data

• Hazardous Substances Data: 1440419-50-0(Hazardous Substances Data)

Upstream product

• 30043-41-5 (hex-5-enyl)magnesium bromide 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 120950-84-7 3-(hex-5-en-1-yl)cyclohex-2-enone 
• 1447869-43-3 C₁₅H₂₅NO₂ 
• 1440419-46-4 3-(hex-5-en-1-yl)-3-(nitromethyl)cyclohexanone 
• 108-98-5 thiophenol 
• 13464-19-2 phenyl chlorothioformate 
• 1440419-49-7 N-{[7-(hex-5-en-1-yl)-1,4-dioxaspiro[4.5]dec-8-en-7-yl]methyl}-1-(4-methoxyphenyl)methanamine 
• 1440419-47-5 5-(hex-5-en-1-yl)-5-(nitromethyl)cyclohex-2-enone 
• 1440419-48-6 9-(hex-5-en-1-yl)-9-(nitromethyl)-1,4-dioxaspiro[4.5]dec-7-ene 
• 39594-84-8 4-methylphenyl chlorothioformate 

Downstream Products

• 1440419-51-1 C₂₈H₃₃NO₃S 

Relevant articles and documents

Catalytic Asymmetric Total Synthesis of Macrocyclic Marine Natural Product (–)-Haliclonin A?

We describe the full details of our total synthesis of haliclonin A, a macrocyclic natural product suggested to originate from a common biosynthetic intermediate as sarain A. Central to our synthetic route is the strategic employment of nitromethane for several purposes: (1) as an umpolung surrogate of an aminomethyl group; (2) as an ideal nucleophile for the highly enantioselective catalytic asymmetric conjugate addition to forge the challenging all-carbon quaternary stereogenic center that was used to induce the formations of all other chiral centers of the molecule; and (3) as a C1N1 building block to form the 3-azabicyclo[3.3.1]nonane framework. The realization of this strategy relied on the development of a novel organocatalytic asymmetric conjugate addition of nitromethane to 3-alkenyl cyclohex-2-enone, and the first Pd-promoted intramolecular coupling of a thiocarbamate moiety onto an electron-deficient alkene (enone) to form the 3-azabicyclo[3,3,1]nonane core. The synthesis also features a SmI2-mediated intermolecular reductive coupling of an enone with an aldehyde, ring-closing alkene and alkyne metathesis reactions to build the two aza-macrocycles, and an unprecedented direct transformation of enol into enone.