1440524-56-0

Basic information

• Product Name: (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate
• Synonyms: (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate
• CAS NO: 1440524-56-0
• Molecular Weight: 318.413
• Mol File: 1440524-56-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate(1440524-56-0)
• EPA Substance Registry System: (S)-1-tert-butyl 3-((R)-1-phenylethyl) 2-methyl-2-allylmalonate(1440524-56-0)

Safety Data

• Hazardous Substances Data: 1440524-56-0(Hazardous Substances Data)

Upstream product

• 37472-52-9 α-methylmalonate mono-tert-butyl ester 
• 1440524-44-6 1-tert-butyl 3-((R)-1-phenylethyl) 2-methylmalonate 
• 106-95-6 allyl bromide 

Downstream Products

• 1517-69-7 (R)-1-phenylethanol 
• 1440524-79-7 (S)-2-((tert-butoxy)carbonyl)-2-methylpent-4-enoic acid 

Relevant articles and documents

Enantioselective phase-transfer catalytic α-alkylation of 2-methylbenzyl tert-butyl malonates

A new asymmetric synthetic method to prepare α,α- dialkylmalonates for the construction of a quaternary carbon center via phase-transfer catalytic (PTC) alkylation has been developed. Enantioselective α-alkylation of 2-methylbenzyl tert-butyl α-methylmalonates under phase-transfer catalytic conditions in the presence of (S,S)-3,4,5- trifluorophenyl-NAS bromide (10) afforded the corresponding α,α- dialkylmalonates in high chemical (up to 99%) and optical yields (up to 91% ee), which were selectively hydrolyzed to malonic monoacids under alkali basic conditions for conversion to versatile chiral intermediates. The Royal Society of Chemistry 2013.