1440805-55-9

Basic information

• Product Name: C₂₅H₃₁ClN₄O₂
• CAS NO: 1440805-55-9
• Molecular Weight: 455
• Mol File: 1440805-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₁ClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₁ClN₄O₂(1440805-55-9)
• EPA Substance Registry System: C₂₅H₃₁ClN₄O₂(1440805-55-9)

Safety Data

• Hazardous Substances Data: 1440805-55-9(Hazardous Substances Data)

Upstream product

• 1440807-84-0 ethyl 2-(2-chlorophenyl)-4,7-dihydro-7-oxo-4-pentylpyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 925000-25-5 ethyl 2-(2-chlorophenyl)-4,7-dihydro-7-oxopyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 126520-01-2 5-amino-3-(2-chlorophenyl)-1H-pyrazole 
• 5452-35-7 cycloheptanamine 
• 1440806-84-7 2-(2-chlorophenyl)-4,7-dihydro-7-oxo-4-pentylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid 

Relevant articles and documents

Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB2 cannabinoid receptor inverse agonists

We recently described the medicinal chemistry of a new series of heteroaryl-4-oxopyridine/7-oxopyrimidines as CB2 receptor partial agonists, showing that the functionality of these ligands is controlled by the nature of the heteroaryl function condensed with the pyridine ring. We describe herein the design and synthesis of the 7-oxopyrazolo[1,5-a]pyrimidine-6- carboxamides, structural isomers of our previously reported pyrazolo[3,4-b] pyridines. All of the new compounds showed high affinity and selectivity for the CB2 receptor in the nanomolar range. In 3,5-cyclic adenosine monophosphate (cAMP) assays, the novel series shows stimulatory effects on forskolin-induced cAMP production acting as inverse agonists.