1442-06-4

Basic information

• Product Name: 4-(METHYLTHIO)BENZOYL CHLORIDE 95
• Synonyms: 4-(METHYLTHIO)BENZOYL CHLORIDE 95;4-(Methylthio)benzoic acid chloride;4-methylsulfanylbenzoyl chloride;4-(Methylthio)benzoyl chloride 95%
• CAS NO: 1442-06-4
• Molecular Formula: C₈H₇ClOS
• Molecular Weight: 186.66
• EINECS: 215-882-4
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 1442-06-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 52-56 °C(lit.)
• Boiling Point: 278.6°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.00422mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(1442-06-4)
• EPA Substance Registry System: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(1442-06-4)

Safety Data

• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 1442-06-4(Hazardous Substances Data)

Usage

General Description

4-(Methylthio)benzoyl chloride 95 is a chemical compound that is commonly used as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. It is a benzoyl chloride derivative with a methylthio (methyl sulfide) group attached to the benzene ring. 4-(METHYLTHIO)BENZOYL CHLORIDE 95 is known for its reactivity as a versatile acylating agent, and it is often employed in the production of pharmaceuticals, dyes, and other fine chemicals. It is also used as a building block in organic synthesis and is valued for its ability to introduce the benzoyl moiety to other organic compounds, making it an important intermediate in the manufacturing of a wide range of chemical products.

InChI:InChI=1/C8H7ClOS/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3

Upstream product

• 13205-48-6 4-(methylthio)benzoic acid 
• 35371-03-0 4-iodothioanisole 
• 122-04-3 4-nitro-benzoyl chloride 
• 100-20-9 terephthaloyl chloride 
• 141-75-3 butyryl chloride 

Downstream Products

• 90005-49-5 4-(methylthio)benzamide 
• 83167-14-0 4-(4-Methylsulfanyl-benzoyl)-1,3-dihydro-imidazol-2-one 
• 103608-34-0 (2-Methyl-1H-indol-3-yl)-(4-methylsulfanyl-phenyl)-methanone 
• 77671-31-9 enoximone 
• 83167-15-1 1,3-dihydro-4-ethyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one 
• 83167-16-2 4-(4-Methylsulfanyl-benzoyl)-5-propyl-1,3-dihydro-imidazol-2-one 
• 94843-65-9 N-(4,6-Dimethyl-pyridin-2-yl)-4-methylsulfanyl-benzamide 
• 126916-56-1 N-[(1S,2S)-2-(2,4-Dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-methylsulfanyl-benzamide 
• 76786-76-0 1-cyano-5-<4-(methylthio)benzoyl>-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole 
• 88777-70-2 3-(4-Methylsulfanyl-benzoyl)-5,6,7,8-tetrahydro-indolizine-8-carbonitrile 
• 76786-66-8 methyl 5-(p-methylthio)benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 81564-98-9 methyl 5-(4-methylthio)benzoyl-6-chloro-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 
• 89542-00-7 6-Methylsulfanyl-5-(4-methylsulfanyl-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester 
• 97483-12-0 ethyl 7-<4-(methylthio)benzoyl>-2,3-dihydrobenzofuran-5-ylacetate 

Relevant articles and documents

Direct Synthesis of Enamides via Electrophilic Activation of Amides

A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.

Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates

An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.

Preparation method of aromatic acyl chloride

The invention discloses a preparation method of aromatic acyl chloride. An aromatic acyl chloride compound is prepared through a reaction of aryl carboxylic acid and phosphorus trichloride. The preparation method of the aromatic acyl chloride has the advantages that the phosphorus trichloride is taken as a chloride reagent, the corresponding acyl chloride is synthesized from the aryl carboxylic acid, so that the production cost is low, the operation is simple, a by-product is low in toxicity, the environmental friendliness is achieved, the yield is high, and the method is conductive to industrial production.