144261-44-9Relevant articles and documents
Nickel-Catalyzed Insertion of Alkynes and Electron-Deficient Olefins into Unactivated sp3 C-H Bonds
Maity, Soham,Agasti, Soumitra,Earsad, Arif Mahammad,Hazra, Avijit,Maiti, Debabrata
supporting information, p. 11320 - 11324 (2015/08/03)
Insertion of unsaturated systems such as alkynes and olefins into unactivated sp3 C-H bonds remains an unexplored problem. We herein address this issue by successfully incorporating a wide variety of functionalized alkynes and electron-deficient olefins into the unactivated sp3 C-H bond of pivalic acid derivatives with excellent syn- and linear- selectivity. A strongly chelating 8-aminoquinoline directing group proved beneficial for these insertion reactions, while an air-stable and inexpensive NiII salt has been employed as the active catalyst. Unactive duty: A wide variety of functionalized alkynes and electron-deficient olefins has been incorporated into the unactivated sp3 C-H bond of pivalic acid derivatives with excellent syn and linear selectivity. A strongly chelating 8-aminoquinoline directing group proved beneficial for these insertion reactions, while an air-stable and inexpensive NiII salt was used as the active catalyst. EWG=electron-withdrawing group.
