1442651-69-5Relevant articles and documents
Synthesis of phospholipid-Ribavirin Conjugates
Oleynikova, Ilona A.,Kulak, Tamara I.,Bolibrukh, Dmitry A.,Kalinichenko, Elena N.
, p. 463 - 472 (2013/05/09)
New conjugates of antiviral nucleoside Ribavirin (=1-(β-D- ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide; 1) with 1,2- and 1,3-diacyl glycerophosphates have been synthesized by the phosphoramidite method. A combination of 2',3'-phenylboronate protecting group for the sugar moiety of the ribonucleoside 1 and 2-cyanoethyl protection for the phosphate fragment ensured the preparation of the desired compounds with reasonable yields via a small number of synthetic steps. Copyright