1443103-66-9

Basic information

• Product Name: tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate
• Synonyms: tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate
• CAS NO: 1443103-66-9
• Molecular Weight: 441.45
• Mol File: 1443103-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate(1443103-66-9)
• EPA Substance Registry System: tert-butyl (8-((4-cyano-3-(trifluoromethyl)phenyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate(1443103-66-9)

Safety Data

• Hazardous Substances Data: 1443103-66-9(Hazardous Substances Data)

Upstream product

• 101066-87-9 4-iodo-2-(trifluoromethyl)benzonitrile 
• 1443103-65-8 tert-butyl (8-amino-1,4-dioxaspiro[4.5]decan-7-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1443103-63-6 (±)-trans-tert-butyl 8-oxo-1,4-dioxaspiro[4.5]decan-7-ylcarbamate 
• 1443103-64-7 tert-butyl (8-((4-methoxybenzyl)amino)-1,4-dioxaspiro[4.5]decan-7-yl)carbamate 

Downstream Products

• 1443103-67-0 4-((7-amino-1,4-dioxaspiro[4.5]decan-8-yl)amino)-2-(trifluoromethyl)benzonitrile 
• 1443103-68-1 4-(2-oxohexahydrospiro[benzo[d]imidazole-5,2′-[1,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile 
• 1443103-85-2 4-(3-methyl-2-oxohexahydrospiro[benzo[d]imidazole-5,2'-[1 ,3]dioxolan]-1(6H)-yl)-2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

CYCLIC UREA DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS

The present invention is directed to compounds of formula (I) wherein R1, R2, R3, and A are defined herein. The present invention also provides for pharmaceutical compositions comprising a compound of formula (I) as well as to the use of such compounds as androgen receptor antagonists for the treatment of diseases and conditions mediated by the androgen receptor, such as prostate cancer.