1443128-07-1

Basic information

• Product Name: C₂₄H₃₀O₆
• Synonyms: C₂₄H₃₀O₆
• CAS NO: 1443128-07-1
• Molecular Weight: 414.499
• Mol File: 1443128-07-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₀O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₀O₆(1443128-07-1)
• EPA Substance Registry System: C₂₄H₃₀O₆(1443128-07-1)

Safety Data

• Hazardous Substances Data: 1443128-07-1(Hazardous Substances Data)

Upstream product

• 2307-69-9 toluene-4-sulfonic acid isopropyl ester 
• 26687-82-1 Arctigenin 

Relevant articles and documents

Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK

A series of new arctigenin and 9-deoxy-arctigenin derivatives bearing different ester and ether side chains at the phenolic hydroxyl positions are designed, synthesized, and evaluated for activating AMPK potency in L6 myoblasts. Initial biological evaluation indicates that some alkyl ester and phenethyl ether arctigenin derivatives display potential activities in AMPK phosphorylation improvement. Further structure-activity relationship analysis shows that arctigenin ester derivatives 3a, 3h and 9-deoxy-arctigenin phenethyl ether derivatives 6a, 6c, 6d activate AMPK more potently than arctigenin. Moreover, the 2-(3,4-dimethoxyphenyl)ethyl ether moiety of 6c has been demonstrated as a potential functional group to improve the effect of AMPK phosphorylation. The structural optimization of arctigenin leads to the identification of 6c as a promising lead compound that exhibits excellent activity in AMPK activation.