144315-91-3

Basic information

• Product Name: Butanoic acid, 1-phenyl-2-[[(phenylmethoxy)carbonyl]amino]ethyl ester, (S)-
• CAS NO: 144315-91-3
• Molecular Formula: C20H23NO4
• Molecular Weight: 341.407
• Mol File: 144315-91-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 1-phenyl-2-[[(phenylmethoxy)carbonyl]amino]ethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 1-phenyl-2-[[(phenylmethoxy)carbonyl]amino]ethyl ester, (S)-(144315-91-3)
• EPA Substance Registry System: Butanoic acid, 1-phenyl-2-[[(phenylmethoxy)carbonyl]amino]ethyl ester, (S)-(144315-91-3)

Safety Data

• Hazardous Substances Data: 144315-91-3(Hazardous Substances Data)

Upstream product

• 371-27-7 2,2,2-trifluoroethylbutyrate 
• 67341-08-6 (+/-)-benzyl 2-hydroxy-2-phenylethylcarbamate 

Downstream Products

• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 

Relevant articles and documents

Lipase Catalysis in the Optical Resolution of 2-Amino-1-phenylethanol Derivatives

The lipase PS- and CCL-catalysed resolution of unsubstituted and N-alkyl substituted 2-amino-1-phenylethanols with 2,2,2-trifluoroethyl butyrate or with butyric anhydride and those of the corresponding diacylated 1,2-amino alcohols with 1-alcohols in organic media have been studied.The enzymatic deacylation of diacylated 2-amino-1-phenylethanol stops at approximately 50percent conversion yielding the two enantiomers with an e.e. of the order of 100percent.Enantioselectivity in the case of N-alkyl substituted compounds is only somewhat lower.Also the enzymatic acylation of 2-amino-1-phenylethanol shows high enantioselectivity when the protection of the NH2 group with CO2Et or CO2CH2Ph has been used.However, the direct acylation of 2-amino-1-phenylethanol or of its N-alkyl substituted derivatives are slow, the reactions stop before 40percent conversion and nonenzymatic aminolysis is usually significant.