1443159-51-0

Basic information

• Product Name: 5-(biphenyl-4-ylmethyl)-N-cyclohexyl-N-methyl-2H-tetrazole-2-carboxamide
• Synonyms: 5-(biphenyl-4-ylmethyl)-N-cyclohexyl-N-methyl-2H-tetrazole-2-carboxamide
• CAS NO: 1443159-51-0
• Molecular Weight: 375.473
• Mol File: 1443159-51-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(biphenyl-4-ylmethyl)-N-cyclohexyl-N-methyl-2H-tetrazole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(biphenyl-4-ylmethyl)-N-cyclohexyl-N-methyl-2H-tetrazole-2-carboxamide(1443159-51-0)
• EPA Substance Registry System: 5-(biphenyl-4-ylmethyl)-N-cyclohexyl-N-methyl-2H-tetrazole-2-carboxamide(1443159-51-0)

Safety Data

• Hazardous Substances Data: 1443159-51-0(Hazardous Substances Data)

Upstream product

• 100-60-7 N-methylcyclohexylamine 
• 35028-38-7 N-methyl-N-cyclohexylaminocarbonyl chloride 

Relevant articles and documents

Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring

In the present study, we have further extended the structure-activity relationships for the tetrazolyl ureas class of compounds as potential FAAH and/or MAGL inhibitors, by replacing the dimethylamino group of the parent compounds 1 and 2 with bulkier groups or by introducing on the distal phenyl ring of 1 and 2 a selected set of substituents. Some of the new compounds (16, 20, 21, 25, and 28) inhibited FAAH potently (IC50 = 3.0-9.7 nM) and selectively (39- to more than 141-fold) over MAGL, while tetrazole 27 turned out to be a promising dual FAAH-MAGL inhibitor of potential therapeutic use. Covalent docking studies on FAAH indicated that the binding modes of tetrazoles 1-32 did not display a unique pattern. The ability of tetrazoles 1-32 to act as TRPV1 and TRPA1 modulators was also investigated.