1443205-03-5

Basic information

• Product Name: C₁₇H₁₁ClN₄OS₂
• Synonyms: C₁₇H₁₁ClN₄OS₂
• CAS NO: 1443205-03-5
• Molecular Weight: 386.886
• Mol File: 1443205-03-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₁ClN₄OS₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₁ClN₄OS₂(1443205-03-5)
• EPA Substance Registry System: C₁₇H₁₁ClN₄OS₂(1443205-03-5)

Safety Data

• Hazardous Substances Data: 1443205-03-5(Hazardous Substances Data)

Upstream product

• 3034-22-8 5-bromo-2-aminothiazole 
• 84772-27-0 6-chloro-3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one 
• 103-72-0 phenyl isothiocyanate 
• 635-21-2 5-chloroanthranilic acid 

Relevant articles and documents

Nonclassical antifolates, part 3: Synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones

A new series of 2-heteroarylthio-6-substituted-quinazolin-4-one analogs was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 21, 25, and 39 proved to be active DHFR inhibitors with IC50 range of 0.3-0.8 μM. Compounds 25, 28, 33, 35 and 36 showed broad spectrum antimicrobial activity comparable to the known antibiotic gentamicin. Compound 29 showed broad spectrum antitumor activity toward several tumor cell lines with GI values range of 25.8-41.2%. Molecular modeling studies concluded that recognition with key amino acid Arg38 and Lys31 are essential for binding and biological activities. Flexible alignment; electrostatic and hydrophobic mappings revealed that the obtained model could be useful for the development of new DHFR inhibitors.