1443538-48-4 Usage
Description
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride is an organic compound with a unique molecular structure featuring a pyrrolidine ring and a substituted phenyl group. It is characterized by the presence of a chlorine atom at the 2nd position and a fluorine atom at the 5th position on the phenyl ring. (R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride is a chiral molecule, with the (R)-configuration indicating the specific arrangement of the atoms in the molecule.
Uses
Used in Pharmaceutical Industry:
(R)-2-(2-chloro-5-fluorophenyl)pyrrolidine hydrochloride is used as a key intermediate in the synthesis of tropomyosin receptor kinase A (TrkA) inhibitors. TrkA is a receptor tyrosine kinase involved in various cellular processes, including cell survival, differentiation, and proliferation. Inhibition of TrkA has been explored as a potential therapeutic strategy for the treatment of various cancers, as it can help prevent tumor growth and progression.
The compound's specific structural features make it a valuable building block for the development of novel TrkA inhibitors with improved potency, selectivity, and pharmacokinetic properties. By incorporating this compound into the design of new drugs, researchers can potentially enhance the effectiveness of TrkA-targeted therapies and provide better treatment options for patients with cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1443538-48-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,3,5,3 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1443538-48:
(9*1)+(8*4)+(7*4)+(6*3)+(5*5)+(4*3)+(3*8)+(2*4)+(1*8)=164
164 % 10 = 4
So 1443538-48-4 is a valid CAS Registry Number.
1443538-48-4Relevant articles and documents
SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
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Paragraph 0561; 0611, (2015/01/06)
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
